DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RpL37a and KCNQ3

DIOPT Version :9

Sequence 1:	NP_001259561.1	Gene:	RpL37a / 32446	FlyBaseID:	FBgn0030616	Length:	93	Species:	Drosophila melanogaster
Sequence 2:	NP_004510.1	Gene:	KCNQ3 / 3786	HGNCID:	6297	Length:	872	Species:	Homo sapiens

Alignment Length:	59	Identity:	14/59 - (23%)
Similarity:	24/59 - (40%)	Gaps:	13/59 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 QKSTCAQCGYPAAKLRSYN---------WSVKAKRRKTTGTGRMQHLKVVRRRFRNGFR 79
            |.|..|..|.|.|:.|.|.         .::||..|..    |:...::.:::|:...|
Human   485 QSSEDAGTGDPMAEDRGYGNDFPIEDMIPTLKAAIRAV----RILQFRLYKKKFKETLR 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RpL37a	NP_001259561.1	PTZ00073	1..91	CDD:240257	14/59 (24%)
KCNQ3	NP_004510.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Ion_trans	139..363	CDD:278921
		Ion_trans_2	269..353	CDD:285168
		Selectivity filter. /evidence=ECO:0000250	316..321
		Mediates interaction with calmodulin. /evidence=ECO:0000269\|PubMed:27564677	356..537		13/55 (24%)
		KCNQ_channel	452..656	CDD:281513	14/59 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	575..611
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	764..872
		KCNQC3-Ank-G_bd	780..866	CDD:288784
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900