DRSC/TRiP Functional Genomics Resources

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Protein Alignment RpL37-1 and KCND1

DIOPT Version :10

Sequence 1:NP_573005.1 Gene:RpL37-1 / 32446 FlyBaseID:FBgn0030616 Length:93 Species:Drosophila melanogaster
Sequence 2:NP_004970.3 Gene:KCND1 / 3750 HGNCID:6237 Length:647 Species:Homo sapiens


Alignment Length:388 Identity:81/388 - (20%)
Similarity:131/388 - (33%) Gaps:134/388 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly    92 FAKVKLAKHVITGHEVAIKIIDKT------------ALNPSSLQKLFREVKIMKQLDHPNIVKLY 144
            |.:|..|     |..:..||::||            |:.||..:|:...|....:|.|       
Human   452 FVEVSFA-----GKMLCSKILEKTANPQWNQNITLPAMFPSMCEKMRIRVMDWDRLTH------- 504

  Fly   145 QVMETEQTLYLVLE--YASGGEVFD---------------------------YLVAHGRMKE--- 177
              .:|..|.||.:.  .|:|||:.:                           |:..:|..:|   
Human   505 --NDTVATTYLGMSKISATGGEIEEEPAGVLKSPQATDLDDNLGFLPTFGPCYVNLYGSPREFTG 567

  Fly   178 -----------KEARAKFRQIVSAVQYLHSKNIIHRDLKAENLLLDQDMNIK----------IAD 221
                       |.....:|..|  :..|.:|.:.|.:.|.|:|..|..:.::          .|.
Human   568 FPDPYAELNTGKGEGVAYRGRV--LLSLETKLVEHSEQKVEDLPADDILRVEKYLRRRKYSLFAA 630

  Fly   222 FGFSNTF---------------SLGNKLDTFCGSPPYAAPELFSGKKYDGPEVDVWSLGVILYTL 271
            | :|.|.               :.|||.||.|  .|.|:...:|...:||........|.:...:
Human   631 F-YSATMLQDVDDAIQFEVSIGNYGNKFDTTC--LPLASTTQYSRAVFDGCHYYYLPWGNVKPVV 692

  Fly   272 VSGSLPFDGQNLKELRERVLRGKYRIPFYMSTDCENLLKKFLVINPQRRS-SLDNIMKDRWMNVG 335
            |..|...|..:..|::.::||...|:.       .||.:..|.:..|..| .:|.:       |.
Human   693 VLSSYWEDISHRIEIQNQLLRVADRLE-------ANLEQVHLALKAQCSSEDVDAL-------VA 743

  Fly   336 YEDDEL-----KPFIE----PPKDQIDEQ----RIEKLIQI------FQLGFNK-AAILESVE 378
            ...|||     :|..:    |....:|:.    |...|.||      .:||.:: :..||..|
Human   744 QLTDELLADCSQPLCDIHEIPSATHLDQYLLRLRTRHLSQIKEAALALKLGHSELSTALEQAE 806

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
RpL37-1NP_573005.1 PTZ00073 1..91 CDD:240257
KCND1NP_004970.3 Interaction with KCNIP1, KCNIP2, and other family members. /evidence=ECO:0000250|UniProtKB:Q63881 2..20
BTB_POZ 6..143 CDD:453885
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 144..163
Ion_trans 185..417 CDD:459842
S4-S5 linker. /evidence=ECO:0000250|UniProtKB:P63142 310..323
Selectivity filter. /evidence=ECO:0000250|UniProtKB:P63142 372..377
DUF3399 470..550 CDD:463381 16/88 (18%)
Required for dendritic targeting. /evidence=ECO:0000250|UniProtKB:Q63881 474..489 3/14 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 506..531 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 601..634 6/33 (18%)
Blue background indicates that the domain is not in the aligned region.

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