DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and CYP4F2

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001073.3	Gene:	CYP4F2 / 8529	HGNCID:	2645	Length:	520	Species:	Homo sapiens

Alignment Length:	549	Identity:	184/549 - (33%)
Similarity:	281/549 - (51%)	Gaps:	93/549 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLALVAFVLW--------------AAFLRYLPKIL--------NFLRLQRFAKT--------- 34
            ||.|:|....||              |::|  |..:|        |..||:.|.:.
Human     1 MSQLSLSWLGLWPVAASPWLLLLLVGASWL--LAHVLAWTYAFYDNCRRLRCFPQPPRRNWFWGH 63

  Fly    35 --LPGPT------IGELIANVKKGEILNWLKELREKHGPVFRIWFGK-DLMVMFTDPEDIKQLLG 90
              :..||      :.:|:|...:|                |::|.|. ..::....|:.|:.::.
Human    64 QGMVNPTEEGMRVLTQLVATYPQG----------------FKVWMGPISPLLSLCHPDIIRSVIN 112

  Fly    91 NNQLLTKSRN--YELLEPWLGKGLLTNGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRR 153
            .:..:.....  |..||||||.|||.:.|:.|.|.|::|||.|||.||..:.:...|:..|:..:
Human   113 ASAAIAPKDKFFYSFLEPWLGDGLLLSAGDKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAK 177

  Fly   154 LRTKANGES--FDIYPYITLFALDAICETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQ 216
            .:..|:..|  .|::.:|:|..||::.:.......|.| :..|||:.|:..:..::.|:......
Human   178 WQLLASEGSACLDMFEHISLMTLDSLQKCVFSFDSHCQ-EKPSEYIAAILELSALVSKRHHEILL 241

  Fly   217 RLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDD-VGAK---RRLAF 277
            .::..:..|..|:....|.:::||.|:.|        ||||....|....|| :.||   :.|.|
Human   242 HIDFLYYLTPDGQRFRRACRLVHDFTDAV--------IQERRRTLPSQGVDDFLQAKAKSKTLDF 298

  Fly   278 LDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASEL-- 340
            :|:|||::.|.|.:|||.|||.|.|||||||||||:|.:::.|..|:|:|:.|:|..:|..||
Human   299 IDVLLLSKDEDGKKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLK 363

  Fly   341 --EGREKE-----SMPYLEAVIKETLRIYPSVPFFSRKVLEDLEV--GKLTVPKGASISCLI--Y 394
              |.:|.|     .:|:|...:||:||::|.||..||.|.:|:.:  |:: :|||  |.|||  :
Human   364 DREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGRV-IPKG--IICLISVF 425

  Fly   395 MLHRDPKNFPDPERFDPDRF-LVNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYR 458
            ..|.:|..:||||.:||.|| ..|.|:..|.||..|||||||||||.|||.|:|..||:.|..:|
Human   426 GTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFAMAEMKVVLALTLLRFR 490

  Fly   459 FLPDKDHQPKPLAELVTKSGNGIRLRILP 487
            .|||.. :|:...|||.::..|:.||:.|
Human   491 VLPDHT-EPRRKPELVLRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	163/462 (35%)
CYP4F2	NP_001073.3	DUF4175	4..>57	CDD:372724	12/54 (22%)
CYP4F2	NP_001073.3	p450	52..515	CDD:365848	167/491 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154684
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650