DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and cyp2j20

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_001337781.3	Gene:	cyp2j20 / 797309	ZFINID:	ZDB-GENE-041210-324	Length:	496	Species:	Danio rerio

Alignment Length:	512	Identity:	122/512 - (23%)
Similarity:	208/512 - (40%)	Gaps:	90/512 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVAFVLWAAFLRYLPKILNFLRLQRFAKTL------PG----PTIGELIANVKKGEILNWLKELR 60
            ::.|..|......|..:..||.|..|.|..      ||    |.||: |.::...::...|.|..
Zfish     3 MLHFYEWIDIKSILIFVCVFLLLSDFIKNKTPKNFPPGPWSLPIIGD-IHHIDPSKLHLQLSEFA 66

  Fly    61 EKHGPVFRI-WFGKDLMVM--FTDPEDIKQLLGNNQLLTKSRNYELLEPWLG-KGLLTNGGESWH 121
            ||:|.:|.: .||..::|:  :...:::....|:|  |.......|....:| |||:.:.|..|.
Zfish    67 EKYGKIFSLRLFGPRIVVLNGYNLVKEVYTQEGDN--LADRAILPLFHDIIGDKGLVASSGYKWK 129

  Fly   122 RRRKLLTPGFHFRILSEF---KEPMEENCRI---LVRRLRTKANGESFDIYPYITLFALDAICET 180
            ::|:     |....|..|   |:.:|.:..:   .:....:...|:.||....:.....:.||..
Zfish   130 QQRR-----FALSTLRNFGLGKKNLEPSINLESGFLNEAISNEQGQPFDPRLLLNNAVSNVICAL 189

  Fly   181 AMG-------IKKHAQLQSDSEYVQAVQSICRVM--------------HKQSFSFWQRLNVFFKH 224
            ..|       .|....|::.:|.|.....||..:              ||:..:.|.:|..|.
Zfish   190 VFGNRFDYSDHKFQTLLKNINETVHLEGGICAQLYNMLPWLMRLLPGPHKRIIALWGKLIEFV-- 252

  Fly   225 TKPGKEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGG 289
                .|:....||.||..|     .|:.:....:|.  |..:||..|                 |
Zfish   253 ----GEKVNEHKVDHDPLN-----PRDYIDCFLDEM--EKHKDDTAA-----------------G 289

  Fly   290 AELSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEG-------REKES 347
            .::.:..|. .:|.|: .|.:|||:.:.:.|..:.|.|::|.:..:|...:.|       .::::
Zfish   290 FDVENLCIC-TLDLFV-AGTETTSTTLYWGLLYMMKYPEIQAKVQQEIDVIVGGSRQPSVSDRDN 352

  Fly   348 MPYLEAVIKETLRIYPSVPF-FSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDP 411
            |||..|||.|..|:...:|. .:|...||.::.|.::|||..::..:..:..|...:..|..|:|
Zfish   353 MPYTNAVIHEIQRMGNIIPINLARTTSEDTQIEKYSIPKGTMVTSNLTSVLFDESEWETPHSFNP 417

  Fly   412 DRFLVNE-KQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQP 467
            ..||..| |.....||..||.|.|.|:|::.|.:||....:.||:.:.|.|....:|
Zfish   418 GHFLDAEGKFRRRDAFLPFSLGKRVCLGEQLARMELFLFFSSLLQRFTFSPPAGVEP 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	114/483 (24%)
cyp2j20	XP_001337781.3	p450	38..492	CDD:278495	114/477 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010