DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and cyp11c1

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_017206857.1	Gene:	cyp11c1 / 791124	ZFINID:	ZDB-GENE-070828-1	Length:	701	Species:	Danio rerio

Alignment Length:	489	Identity:	125/489 - (25%)
Similarity:	187/489 - (38%)	Gaps:	109/489 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 WLKELR----------EKH--------GPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNY 101
            |:..||          .||        ||::|...|....|....|.|..:|..:..|..:...
Zfish   233 WMNLLRFWRDGRFSRMHKHMEESFRRLGPIYREHLGSQSSVNIMLPMDTGELFRSEGLHPRRMT- 296

  Fly   102 ELLEPWL--------GKGLLTNGGESWHRRRKLL------TPGFHFRILSEFKEPMEENCRILVR 152
              |:||.        .||:....|..|...|.||      :...| |.|....|..::.||.|.|
Zfish   297 --LQPWATHRETRRHSKGVFLKNGTEWRADRLLLNREVMVSSSVH-RFLPLLDEVAQDFCRSLRR 358

  Fly   153 RLRT----KANGE--SFDIYPYITLFALDAICETAMG--IKKHAQLQSD--SEYVQAVQSIC--- 204
            |::.    ||...  :.|..|.:..|||:|.|....|  |...:...||  ..::.||:.:.
Zfish   359 RVQADGFEKAGQHTLTLDPSPDLFRFALEASCHVLYGERIGLFSSCPSDESERFISAVERMLATT 423

  Fly   205 --------RVMHKQSFSFW----QRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRRE-QLIQE 256
                    |::.:...|.|    ...:..|.|.:.                   |::|. |.:|.
Zfish   424 PPLLYLPPRLLLRLRASLWTTHATAWDDIFSHAEQ-------------------RIQRSYQRLQA 469

  Fly   257 RNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFALS 321
            |....|:.....|..|            .||.| :||...||..:...|..|.|||:..:.|||.
Zfish   470 RPSAAPDCSFPGVLGK------------LMEAG-QLSLELIRANITELMAGGVDTTAVPLQFALF 521

  Fly   322 LLSKNPDVQQ-------RAFEEASELEGREKESMPYLEAVIKETLRIYPSVPFFSRKVLEDLEVG 379
            .|::|||||:       .::::||....:..:..|.|:..||||||:||......|..:.|:.:.
Zfish   522 ELARNPDVQECVRAQVLSSWQQASGDPLKALQGAPLLKGTIKETLRLYPVGITVQRYPVRDIVLQ 586

  Fly   380 KLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEK--QMHPFAFAAFSAGPRNCIGQKFA 442
            ...||.|..:...:|.|.|..:.|..||.|||.|:..:..  ....|...||..|.|.|:|::.|
Zfish   587 NYHVPAGTLVQVCLYPLGRSAEVFSRPECFDPSRWSADADAGSAGGFRSLAFGFGSRQCVGRRIA 651

  Fly   443 MLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTK 476
            ..|::..|..:||:::.......      ||.||
Zfish   652 ENEMQLLLMHILRTFKLTVSSTE------ELSTK 679

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	121/480 (25%)
cyp11c1	XP_017206857.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910