DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4s3 and Cyp4f16

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001343232.1	Gene:	Cyp4f16 / 70101	MGIID:	1917351	Length:	524	Species:	Mus musculus

Alignment Length:	518	Identity:	172/518 - (33%)
Similarity:	270/518 - (52%)	Gaps:	54/518 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LALVAFVLWAAFLRYLPKIL--------NFLRLQRFAKTLPGPT--------IGELIANVKKGEI 52
            |.|:....|     .|.:||        |..||..|    |.|.        :|.:.:|   .|.
Mouse    21 LLLLGVASW-----ILARILAWTYSFYENCSRLSCF----PQPPKKNWFSGHLGMIQSN---EEG 73

  Fly    53 LNWLKELREKHGPVFRIWFGKDLMVM-FTDPEDIKQLLGNNQLLT-KSRNY-ELLEPWLGKGLLT 114
            :..:.|:.:....|...|.|..:.|: ..||..:..||....|:. |...: ..|:||||.||..
Mouse    74 MQLVTEMGQTFQDVHLFWLGPVIPVLRIVDPAFVAPLLQAPALVAPKDMTFLRFLKPWLGDGLFL 138

  Fly   115 NGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLR--TKANGESFDIYPYITLFALDAI 177
            :.|:.|.|.|:||||.|||.||..:.:...::..|:..:.:  :.......:::.:|:|..||::
Mouse   139 SSGDKWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLSSEGSARLEMFEHISLMTLDSL 203

  Fly   178 CETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDET 242
            .:...|...:.| :|.|||:.|:..:..::.|:|...:..::..:.||..|:....|..::|:.|
Mouse   204 QKCLFGFDSNCQ-ESPSEYISAILELSSLIIKRSLQLFLFVDFLYYHTADGRRFRKACDLVHNFT 267

  Fly   243 NRVIRLRREQL-IQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMF 306
            :.|||.||..| .|..:|:.....:     .:.|.|:|:|||.:.|.|.||||.|||.|.|||||
Mouse   268 DAVIRERRHTLSSQNHDEFLKSKTK-----SKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMF 327

  Fly   307 EGHDTTSSAIAFALSLLSKNPDVQQRAFEEASE-LEGREKE--------SMPYLEAVIKETLRIY 362
            .|||||:||:::.|..|:::|:.|:|..:|..| |..||.|        .:|:|...|||:||::
Mouse   328 GGHDTTASALSWILYNLARHPEYQERCRQEVQELLRDREPEEIEWDDLAQLPFLTMCIKESLRLH 392

  Fly   363 PSVPFFSRKVLEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LVNEKQMHPF 424
            ..|....|:...|:.:  |:: :|||......|:.:|.:|..:||||.:||.|| ..|.::..|.
Mouse   393 SPVIDLLRRCTRDIVLPDGRV-IPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENPQKRSPL 456

  Fly   425 AFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILP 487
            ||..|||||||||||.|||.|:|.:||:.|..:|.||| |.:|:...|::.::..|:.||:.|
Mouse   457 AFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFRILPD-DKEPRRKPEIILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	157/459 (34%)
Cyp4f16	NP_001343232.1	p450	52..514	CDD:306555	159/472 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844993
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650