DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4s3 and Cyp4f37

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_038935973.1	Gene:	Cyp4f37 / 691312	RGDID:	1585102	Length:	526	Species:	Rattus norvegicus

Alignment Length:	524	Identity:	178/524 - (33%)
Similarity:	270/524 - (51%)	Gaps:	58/524 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LALVAFVLWAAFLRYLPKIL--------NFLRLQRFAKTLPGPT----IGELIANVKKGEILNWL 56
            |.|:....|     .|.:||        |..||:.|.::   |.    :|.|.......|.:..:
  Rat    21 LLLLGAASW-----ILARILAWTYSFCENCSRLRCFPQS---PKRNWFLGHLGVIQSNEEGMQLV 77

  Fly    57 KELREKHGPVFRIWFGKDLMVM-FTDPEDIKQLLGNNQLLT-KSRNY-ELLEPWLGKGLLTNGGE 118
            .|:.:....|..||.|....|: ..||..:..||....|:. |...: ..|:||||.||..:.|:
  Rat    78 TEMGQTFRDVHLIWLGPVSPVLRLVDPAFVAPLLQAPALVAPKDPTFLHFLKPWLGDGLFLSSGD 142

  Fly   119 SWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRR-----LRTKANGESFDIYPYITLFALDAIC 178
            .|.|.|:||||.|||.||..:.:...::..|:..:     |...|..|.|:   .|:|..||::.
  Rat   143 KWSRHRRLLTPAFHFDILKPYVKTFNQSVNIMHAKWKHLCLEGSARLEMFE---NISLMTLDSLQ 204

  Fly   179 ETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETN 243
            :...|...:.| :|.|||:.|...:..:..|:|:..:..|:..:..|..|:....|..::|..|:
  Rat   205 KCLFGFDSNCQ-ESPSEYISATLELSSLTRKRSYKLFLYLDFLYYRTADGQRFRKACDLVHSFTD 268

  Fly   244 RVIRLRREQL----IQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTF 304
            .|||.||..|    :.|..|.|.:::      .:.|.|:|:|||.:.|.|.||||.|||.|.|||
  Rat   269 AVIRERRRLLSSQGVDEFLESKTKSK------SKTLDFIDVLLLAKDEHGKELSDEDIRAEADTF 327

  Fly   305 MFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASE-LEGREKE--------SMPYLEAVIKETLR 360
            ||.|||||:||:::.|..|:.:|:.|:|..:|..| |..||.|        .:|:|...|||:||
  Rat   328 MFGGHDTTASALSWILYNLASHPEYQERCRQEVWELLRDREPEEIEWDDLAQLPFLTMCIKESLR 392

  Fly   361 IYPSVPFFSRKVLEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LVNEKQMH 422
            ::|......|:..:|:.:  |:: :|||......|:.:|.:|..:||||.:||.|| ..|.::..
  Rat   393 LHPPAVDLLRRCTQDIVLPDGRV-IPKGNICVISIFGIHHNPSVWPDPEVYDPFRFDPENRQKRS 456

  Fly   423 PFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRI-- 485
            |.:|..|||||||||||.|||.|:|.::.:.|..:||||| |.:|:...||:.::..|:.||:
  Rat   457 PLSFIPFSAGPRNCIGQTFAMNEVKVAVGLTLLRFRFLPD-DKEPRRKPELILRAEGGLWLRVEL 520

  Fly   486 LPRD 489
            |.||
  Rat   521 LSRD 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	160/461 (35%)
Cyp4f37	XP_038935973.1	CYP4F	74..517	CDD:410772	159/454 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348432
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750