DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and CYP4F12

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_076433.3	Gene:	CYP4F12 / 66002	HGNCID:	18857	Length:	524	Species:	Homo sapiens

Alignment Length:	538	Identity:	181/538 - (33%)
Similarity:	281/538 - (52%)	Gaps:	71/538 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLAL-------VAFVLWAAFLR-----YLPKIL--------NFLRLQRFAKTLPGPT------ 39
            ||.|:|       ||...|...|.     .|.:||        |..|||.|    |.|.
Human     1 MSLLSLPWLGLRPVATSPWLLLLLVVGSWLLARILAWTYAFYNNCRRLQCF----PQPPKRNWFW 61

  Fly    40 --IGELIANVKKGEILNWLKELREKHGPVFRIWFGKDL-MVMFTDPEDIKQLLGNNQLLTKSRN- 100
              :| ||...::|  |....::...:...|.:|.|..: .::...|:.|:.:...:..:....|
Human    62 GHLG-LITPTEEG--LKNSTQMSATYSQGFTVWLGPIIPFIVLCHPDTIRSITNASAAIAPKDNL 123

  Fly   101 -YELLEPWLGKGLLTNGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKAN-GES- 162
             ...|:||||:|:|.:||:.|.|.|::|||.|||.||..:.....::..|::.:.:..|: |.|
Human   124 FIRFLKPWLGEGILLSGGDKWSRHRRMLTPAFHFNILKSYITIFNKSANIMLDKWQHLASEGSSR 188

  Fly   163 FDIYPYITLFALDAICETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKP 227
            .|::.:|:|..||::.:.......|.| :..|||:..:..:..::.|:|....|.::..:..:..
Human   189 LDMFEHISLMTLDSLQKCIFSFDSHCQ-ERPSEYIATILELSALVEKRSQHILQHMDFLYYLSHD 252

  Fly   228 GKEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDV----GAKRRLAFLDMLLLTQMEG 288
            |:....|.:::||.|:.|||.||..|        |....||.    ...:.|.|:|:|||::.|.
Human   253 GRRFHRACRLVHDFTDAVIRERRRTL--------PTQGIDDFFKDKAKSKTLDFIDVLLLSKDED 309

  Fly   289 GAELSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASEL---------EGRE 344
            |..|||.|||.|.|||||.|||||:|.:::.|..|:::|:.|:|..:|..||         |..:
Human   310 GKALSDEDIRAEADTFMFGGHDTTASGLSWVLYNLARHPEYQERCRQEVQELLKDRDPKEIEWDD 374

  Fly   345 KESMPYLEAVIKETLRIYPSVPFFSRKVLEDLEV--GKLTVPKGASISCLIYML--HRDPKNFPD 405
            ...:|:|...:||:||::|..||.||...:|:.:  |:: :|||  |:|||.::  |.:|..:||
Human   375 LAQLPFLTMCVKESLRLHPPAPFISRCCTQDIVLPDGRV-IPKG--ITCLIDIIGVHHNPTVWPD 436

  Fly   406 PERFDPDRF-LVNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKP 469
            ||.:||.|| ..|.|...|.||..|||||||||||.|||.|:|..||::|..:|||||.. :|:.
Human   437 PEVYDPFRFDPENSKGRSPLAFIPFSAGPRNCIGQAFAMAEMKVVLALMLLHFRFLPDHT-EPRR 500

  Fly   470 LAELVTKSGNGIRLRILP 487
            ..||:.::..|:.||:.|
Human   501 KLELIMRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	159/464 (34%)
CYP4F12	NP_076433.3	p450	52..506	CDD:306555	161/469 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154696
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	8	7.650