DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp3a57

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001093650.1	Gene:	Cyp3a57 / 622127	MGIID:	3646373	Length:	503	Species:	Mus musculus

Alignment Length:	516	Identity:	140/516 - (27%)
Similarity:	243/516 - (47%)	Gaps:	59/516 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEILNWL-------KELREK 62
            :||.|.::..:...|.|.|.          :|||....|.     |.|:|:|       .:..:|
Mouse    18 SLVFFYIYGTYSHGLFKKLG----------IPGPKPLPLF-----GNIINYLDGMWKFDDDCYKK 67

  Fly    63 HGPVFRIWFGKDLMVMFTDPEDIKQLLGNN--QLLTKSRNYELLEPWLGKGLLTNGGESWHRRRK 125
            :|.::..:.|...::...|||.||.:|...  .:.|..|.:..: .:|.|.:..:..|.|.|.|.
Mouse    68 YGKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRPFGPV-GFLKKSITISEDEEWKRLRT 131

  Fly   126 LLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGES-FDIYPYITLFALDAICETAMGIKKHAQ 189
            ||:|.|....|.|....|.:...||||.||.:...|. .::......:::|.|..|:.|:...:.
Mouse   132 LLSPTFTSSKLKEMFPIMRQYGDILVRNLRREEEKEEPINMKDIFGAYSMDVITGTSCGVNIDSL 196

  Fly   190 LQSDSEYVQAVQSICRVMHKQSFSFWQRL---NVFFKHTKPGKEREAALKVLHDETNRVIRLRRE 251
            ......:||.::.|.:      |.|:...   .|.|....|          :::..|..|..|:.
Mouse   197 NNPQDPFVQKIKKILK------FKFFDPFLLSVVLFPFLTP----------IYEMLNLSIFPRQS 245

  Fly   252 QLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAE----LSDTDIREEVDTFMFEGHDTT 312
            ....::...|.:.::.|...|.|:.||.:::.||...|.|    |||.::..:...|:|.|:|.|
Mouse   246 MNFFKKFVKKMKKDRLDYNQKNRVDFLQLMMNTQNSKGQESLKALSDLEMAAQTLIFIFGGYDGT 310

  Fly   313 SSAIAFALSLLSKNPDVQQ-------RAFEEASELEGREKESMPYLEAVIKETLRIYPSVPFFSR 370
            |::|:|.:..|:.:||||:       ||....:.:.......|.||:.|:.|:||:||.|....|
Mouse   311 STSISFIMYELATHPDVQKKLQDEIDRALPNKAPVTYDALMDMEYLDMVVNESLRLYPVVSRIDR 375

  Fly   371 KVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LVNEKQMHPFAFAAFSAGPR 434
            ...:|:|:..:.:|||..:...||.|||||:.:|:||.|.|:|| ..|:..:.|:.:..|..|||
Mouse   376 FSKKDVEIHGVFIPKGTIVMIPIYPLHRDPEYWPEPEDFCPERFSKENKGNIDPYIYMPFGNGPR 440

  Fly   435 NCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQ-PKPLA-ELVTKSGNGIRLRILPRDENGT 493
            ||||.:||::.:|.::..:|:::...|.::.| |..:: :.:.:....|.|:.:.||:..|
Mouse   441 NCIGMRFALISVKLAVTGVLQNFTVQPCEETQIPVKISRQPIFRPEKPIILKFVSRDKPRT 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	129/459 (28%)
Cyp3a57	NP_001093650.1	p450	39..493	CDD:278495	131/475 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820