DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and CYP20A1

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001358624.1	Gene:	CYP20A1 / 57404	HGNCID:	20576	Length:	470	Species:	Homo sapiens

Alignment Length:	514	Identity:	123/514 - (23%)
Similarity:	215/514 - (41%)	Gaps:	98/514 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVAFVLWAA--FLRYLPKILNFLRLQRFAKTLPG--PT---IGELIANVKKGEILNWLKELREKH 63
            ::.|.::|.  .|..:..:|......|.|..:||  ||   .|.|...|..|.:..:|..|.|::
Human     1 MLDFAIFAVTFLLALVGAVLYLYPASRQAAGIPGITPTEEKDGNLPDIVNSGSLHEFLVNLHERY 65

  Fly    64 GPVFRIWFGKDLMVMFTDPEDIKQLLGNN------QLLTKSRNYELLEPWLGKGLLTNGGESWHR 122
            |||...|||:.|:|.....:.:||.:..|      :.:.||    ||....|.|.::..    |.
Human    66 GPVVSFWFGRRLVVSLGTVDVLKQHINPNKTSDPFETMLKS----LLRYQSGGGSVSEN----HM 122

  Fly   123 RRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGESFD---IYP---YITL------FALD 175
            |:||...|....:.|.|             .|..|.:.|..|   .||   ::.|      ||:.
Human   123 RKKLYENGVTDSLKSNF-------------ALLLKLSEELLDKWLSYPETQHVPLSQHMLGFAMK 174

  Fly   176 AICETAMGIKKHAQLQSDSEYVQAVQ---SICRVMHKQSFSFWQRLNVFF------KHTKPGKER 231
            ::.:..||    :..:.|.|.::..:   ::|...:   |..|..:...|      |:....|:.
Human   175 SVTQMVMG----STFEDDQEVIRFQKNHGTLCIFTY---FQVWSEIGKGFLDGSLDKNMTRKKQY 232

  Fly   232 EAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTD 296
            |.||..|......:|:.|:.:...:.                  .|:|.|    ::|  .|:|..
Human   233 EDALMQLESVLRNIIKERKGRNFSQH------------------IFIDSL----VQG--NLNDQQ 273

  Fly   297 IREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGR-----EK-ESMPYLEAVI 355
            |.|:...|.......|:....:|:..|:.:.:||::.:||.:::.|.     || |.:.|.:.|:
Human   274 ILEDSMIFSLASCIITAKLCTWAICFLTTSEEVQKKLYEEINQVFGNGPVTPEKIEQLRYCQHVL 338

  Fly   356 KETLRIYPSVPFFSRKVLEDLE--VGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNE 418
            .||:|.....|..::  |:|:|  :.:..:|:...:...:.::.:||..:|.|.:|||||| .:|
Human   339 CETVRTAKLTPVSAQ--LQDIEGKIDRFIIPRETLVLYALGVVLQDPNTWPSPHKFDPDRF-DDE 400

  Fly   419 KQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKS 477
            ..|..|:...|| |.:.|...:||.:.....|::|::....|..:....:...||||.|
Human   401 LVMKTFSSLGFS-GTQECPELRFAYMVTTVLLSVLVKRLHLLSVEGQVIETKYELVTSS 458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	112/473 (24%)
CYP20A1	NP_001358624.1	p450	43..454	CDD:386267	108/466 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910