Protein Alignment Cyp4s3 and CYP26B1

DIOPT Version :10

• Sequence 1: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_063938.1
• Gene: CYP26B1 / 56603
• HGNCID: 20581
• Length: 512
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 123/538 - (22%)
• Similarity: 210/538 - (39%)
• Gaps: 122/538 - (22%)

  Fly     1 MSTLA--LVAFVLWAAFLRYLPKILNFLRLQRFAKT--------LPGPTIG-ELIANVKKGEILN 54
            ::|||  ||:..|..|..:.|.::       |:|.|        :|..::| .||     ||..:
Human    12 LATLAACLVSVTLLLAVSQQLWQL-------RWAATRDKSCKLPIPKGSMGFPLI-----GETGH 64

  Fly    55 WL-------KELREKHGPVFRIWFGKDLMVMFTDPEDIKQ-LLGNNQLLTKS--RNYELLEPWLG 109
            ||       ...|||:|.||:.......::..|..|:::: |:|.:.|::..  |:..:|   ||
Human    65 WLLQGSGFQSSRREKYGNVFKTHLLGRPLIRVTGAENVRKILMGEHHLVSTEWPRSTRML---LG 126

  Fly   110 KGLLTNG-GESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFA 173
            ...::|. |:....:||:.:..|....|..:                          .|.|.|..
Human   127 PNTVSNSIGDIHRNKRKVFSKIFSHEALESY--------------------------LPKIQLVI 165

  Fly   174 LDAICETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVL 238
            .|.             |::.|.:.:|:..   ....|..:|...:.|....:.|.::.....:|.
Human   166 QDT-------------LRAWSSHPEAINV---YQEAQKLTFRMAIRVLLGFSIPEEDLGHLFEVY 214

  Fly   239 HDETNRVIRL---------RR----EQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGA 290
            ....:.|..|         ||    .|::|:..|.....:......|..|..||:|:.:..|.|.
Human   215 QQFVDNVFSLPVDLPFSGYRRGIQARQILQKGLEKAIREKLQCTQGKDYLDALDLLIESSKEHGK 279

  Fly   291 ELSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEE----------ASELEGREK 345
            |::..::::.....:|..:.||:||....:..|.|:|.|.::..:|          ....||..:
Human   280 EMTMQELKDGTLELIFAAYATTASASTSLIMQLLKHPTVLEKLRDELRAHGILHSGGCPCEGTLR 344

  Fly   346 ----ESMPYLEAVIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDP 406
                ..:.||:.||||.:|::..:....|.||:..|:....:|||.|:...|...|.....|.|.
Human   345 LDTLSGLRYLDCVIKEVMRLFTPISGGYRTVLQTFELDGFQIPKGWSVMYSIRDTHDTAPVFKDV 409

  Fly   407 ERFDPDRF--LVNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKP 469
            ..||||||  ..:|.:...|.:..|..|.|.|:|:..|.|.||.....|..:.||
Human   410 NVFDPDRFSQARSEDKDGRFHYLPFGGGVRTCLGKHLAKLFLKVLAVELASTSRF---------- 464

  Fly   470 LAELVTKSGNGIRLRILP 487
              ||.|::..  |:.::|
Human   465 --ELATRTFP--RITLVP 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	CYP4	64..483	CDD:410721	99/451 (22%)
CYP26B1	NP_063938.1	CYP26B1	60..490	CDD:410730	108/478 (23%)