DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	534	Identity:	135/534 - (25%)
Similarity:	239/534 - (44%)	Gaps:	95/534 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEILNWL-------KELREK 62
            :||.|.::..:...|.|.|.          :|||....|:     |.|.|:.       ::..:|
Mouse    18 SLVLFYIYGTYSHGLFKKLG----------IPGPKPLPLL-----GTIFNYYDGMWKFDEDCYKK 67

  Fly    63 HGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEP--WLGKGLLTNGGESWHRRRK 125
            :|.::..:.|...::...|||.||.:| ..:..:...|.....|  ::.|.:..:..|.|.|.|.
Mouse    68 YGKIWGFYEGPQPILAIMDPEIIKIVL-VKECYSVFTNRRFFGPVGFMKKAITISEDEEWKRLRT 131

  Fly   126 LLTPGFHFRILSEFKEPMEENCRILVRRL-RTKANGESFDIYPYITLFALDAICETAMGIKKHAQ 189
            ||:|.|....|.|....|.:...||||.| |.:..||...:......:::|.|..|:.|:...:.
Mouse   132 LLSPTFTSGKLKEMFPIMRQYGDILVRNLRREEEKGEPISMKDIFGAYSMDVITGTSFGVNVDSL 196

  Fly   190 LQSDSEYVQAVQSICR-------------------VMHKQSFSFWQR--LNVFFKHTKPGKEREA 233
            ......:||..:.|.:                   :....:||.:.|  :|.|.|..|
Mouse   197 NNPQDPFVQKAKKILKFKIFDPFLLSIILFPFLTPIYEMLNFSIFPRDSMNFFKKFVK------- 254

  Fly   234 ALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAE----LSD 294
                         |:::|:|...:              |.|:.||.:::.||...|.|    |||
Mouse   255 -------------RMKKERLASNQ--------------KNRVDFLQLMMNTQNSKGQESQKALSD 292

  Fly   295 TDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGREKE-------SMPYLE 352
            .::..:...|:|.|:|.||::|:..:..|:.:||||::..:|.......:..       .|.||:
Mouse   293 LEMAAQAVIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTLPNKAPVTYDALMDMEYLD 357

  Fly   353 AVIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LV 416
            .|:.|:||:||......|...:|:|:..:.:|||..:...||.|||:|:.:|:|:.|.|:|| ..
Mouse   358 MVVNESLRLYPIAIRLERVSKKDVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFCPERFSKE 422

  Fly   417 NEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQ-PKPLA-ELVTKSGN 479
            |:..:.|:.:..|..|||||||.:||::.:|.::..:|:::...|.::.| |..:: |.:.:...
Mouse   423 NKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEETQIPLKISREPIFQPEK 487

  Fly   480 GIRLRILPRDENGT 493
            .|.|:::.||:..|
Mouse   488 PIILKVVSRDKPRT 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	123/477 (26%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	126/493 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810