DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4s3 and Cyp4f1

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_062569.2	Gene:	Cyp4f1 / 56266	RGDID:	70926	Length:	524	Species:	Rattus norvegicus

Alignment Length:	549	Identity:	191/549 - (34%)
Similarity:	284/549 - (51%)	Gaps:	93/549 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLAL--------VAFVLWAAFLRY-----LPKIL--------NFLRLQRFAKTLPGPT----- 39
            ||.|:|        |||. |...|.:     |.:||        ||.||:.|    |.|.
  Rat     1 MSQLSLSWLGLGPEVAFP-WQTLLLFGASWILAQILTQIYAAYRNFRRLRGF----PQPPKRNWL 60

  Fly    40 ---IGELIANVKKGEILNWLKELREKHGPV---FRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKS 98
               :| ::...::|     ||||....|..   |.:|.|..:.|:.....||.:.:.|.......
  Rat    61 MGHVG-MVTPTEQG-----LKELTRLVGTYPQGFLMWIGPMVPVITLCHSDIVRSILNASAAVAL 119

  Fly    99 RN---YELLEPWLGKGLLTNGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRIL-VRRLRTKAN 159
            ::   |.:|:||||.|||.:.|:.|.|.|::|||.|||.||..:.:...::..|: .:..|..:.
  Rat   120 KDVIFYTILKPWLGDGLLVSAGDKWSRHRRMLTPAFHFNILKPYVKIFNDSTNIMHAKWKRLISE 184

  Fly   160 GES-FDIYPYITLFALDAICETAMGIKKHAQLQSDSEYVQAVQSICRVM---HKQSFSFWQRLNV 220
            |.| .|::.:::|..||::.:.......:.| :..|||:.|:..:..::   |:|...|   :::
  Rat   185 GSSRLDMFEHVSLMTLDSLQKCVFSFDSNCQ-EKSSEYIAAILELSALVAKRHQQPLLF---MDL 245

  Fly   221 FFKHTKPGKEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDV----GAKRRLAFLDML 281
            .:..|..|.....|..::|:.|:.|||.||..|        |:...|:.    ...:.|.|:|:|
  Rat   246 LYNLTPDGMRFHKACNLVHEFTDAVIRERRRTL--------PDQGLDEFLKSKAKSKTLDFIDVL 302

  Fly   282 LLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASE-LEGREK 345
            |||:.|.|.||||.|||.|.|||||||||||:|.:::.|..|:|:|:.|:|..:|..| |..|:.
  Rat   303 LLTKDEDGKELSDEDIRAEADTFMFEGHDTTASGLSWILYNLAKHPEYQERCRQEVQELLRDRDP 367

  Fly   346 E--------SMPYLEAVIKETLRIYPSVPFFSRKVLED--LEVGKLTVPKGASISCL--IYMLHR 398
            |        .:|:|...|||:||::|.|...||...:|  |..|: |:|||  |.||  |:.:|.
  Rat   368 EEIEWDDLAQLPFLTMCIKESLRLHPPVTVISRCCTQDILLPDGR-TIPKG--IICLISIFGIHH 429

  Fly   399 DPKNFPDPE-----RFDPDRFLVNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYR 458
            :|..:||||     ||||:    |.|...|.||..|||||||||||.|||.|:|.:||:.|..:|
  Rat   430 NPSVWPDPEVYNPFRFDPE----NIKDSSPLAFIPFSAGPRNCIGQTFAMSEMKVALALTLLRFR 490

  Fly   459 FLPDKDHQPKPLAELVTKSGNGIRLRILP 487
            .||| |.:|:...||:.::..|:.||:.|
  Rat   491 LLPD-DKEPRRQPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	168/474 (35%)
Cyp4f1	NP_062569.2	CYP4F	74..515	CDD:410772	167/460 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348446
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650