DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and cyp4v7

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001073465.1	Gene:	cyp4v7 / 562008	ZFINID:	ZDB-GENE-061103-88	Length:	510	Species:	Danio rerio

Alignment Length:	508	Identity:	207/508 - (40%)
Similarity:	299/508 - (58%)	Gaps:	25/508 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPG-----PTIGELIA-NVKKGEILNWLKE- 58
            :..|.....:|..|...|.| :.|::......:.:||     |.||..:. ....|:..|.:.|
Zfish    10 LGILFTAVLLLLLASTAYNP-LKNYIGKWNEMRPIPGMAGAYPIIGNALQFKTNAGDFFNQIIEG 73

  Fly    59 -LREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHR 122
             ...:|.|:.::|.|....::....|:|:.:|.|::.|.||.:|..|.||||.||||:.||.|..
Zfish    74 TNENRHLPLAKVWVGPVPFLILYHAENIEVVLSNSRHLDKSYSYRFLHPWLGTGLLTSTGEKWRN 138

  Fly   123 RRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMGIKKH 187
            |||:|||.|||.|||:|.|.|.|...||:::::...:||.|:.:.:|||.|||.|||||||.|.:
Zfish   139 RRKMLTPTFHFSILSDFLEVMNEQTDILIQKMQKLEDGEPFNCFNFITLCALDIICETAMGKKIY 203

  Fly   188 AQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQ 252
            ||..:||||||:|..:..::.|:..:.|...:..:...|.|||....||:||..|..|||.|.|.
Zfish   204 AQSNADSEYVQSVYKMSDIITKRQRAPWLWPDWIYNKLKEGKEHAKRLKILHSFTANVIRERAEF 268

  Fly   253 LIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIA 317
            :..|     |:::.|. |.::|.|||||||.|..|.|.:||..||:||||||||||||||::::.
Zfish   269 MSSE-----PDSDSDQ-GERKRQAFLDMLLKTTYENGQKLSHEDIQEEVDTFMFEGHDTTAASMN 327

  Fly   318 FALSLLSKNPDVQQRAFEEASELEG--------REKESMPYLEAVIKETLRIYPSVPFFSRKVLE 374
            :||.|:..:|:||:....|..|:.|        .:.:.:.|||.||||:|||:||||.|:|.:.|
Zfish   328 WALHLIGSHPEVQKAVQAELQEVFGSSERHVGVEDLKKLRYLECVIKESLRIFPSVPLFARSICE 392

  Fly   375 DLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFL-VNEKQMHPFAFAAFSAGPRNCIG 438
            ...:....||||.:...:.|.|||||:.||:||.|.|:||: .|.|..||:|:..||||||||||
Zfish   393 ACHINGFKVPKGVNAVIIPYALHRDPRYFPEPEEFQPERFMPENSKGRHPYAYIPFSAGPRNCIG 457

  Fly   439 QKFAMLELKTSLAMLLRSYRFLPDKDHQP-KPLAELVTKSGNGIRLRILPRDE 490
            |:|||:|.|..||.:||.:.....:..:. :||.||:.:...||.:::..|.:
Zfish   458 QRFAMMEEKVVLATILRHFDVEACQSREELRPLGELILRPEKGIWIKLQRRSK 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	194/451 (43%)
cyp4v7	NP_001073465.1	p450	44..505	CDD:278495	200/466 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170589825
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.850