DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4a1

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_787031.1	Gene:	Cyp4a1 / 50549	RGDID:	68945	Length:	509	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	172/513 - (33%)
Similarity:	264/513 - (51%)	Gaps:	65/513 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 RYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEIL---NW-LKELREKHGPVFRIWFG----- 72
            |:...|..||::        ...:|.|:..||..:..   .| ||..::...|.|..:||
  Rat    10 RFTGSISGFLQV--------ASVLGLLLLLVKAVQFYLQRQWLLKAFQQFPSPPFHWFFGHKQFQ 66

  Fly    73 --KDLMVMFT-----------------------DPEDIKQLLGNNQLLTKSRN-YELLEPWLGKG 111
              |:|..:.|                       ||:.:|.:||.:.  .|:.. |.||.||:|.|
  Rat    67 GDKELQQIMTCVENFPSAFPRWFWGSKAYLIVYDPDYMKVILGRSD--PKANGVYRLLAPWIGYG 129

  Fly   112 LLTNGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGE-SFDIYPYITLFALD 175
            ||...|:.|.:.|::|||.||:.||..:.:.|.::.|:::.:....|..: |.:|:.:|:|..||
  Rat   130 LLLLNGQPWFQHRRMLTPAFHYDILKPYVKNMADSIRLMLDKWEQLAGQDSSIEIFQHISLMTLD 194

  Fly   176 AICETAMGIKKHAQLQSD-SEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLH 239
            .:.:.|.......|:..: ..|:||:.::..:.|.:..:.:.:.:..:..:..|.....|.::.|
  Rat   195 TVMKCAFSHNGSVQVDGNYKSYIQAIGNLNDLFHSRVRNIFHQNDTIYNFSSNGHLFNRACQLAH 259

  Fly   240 DETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTF 304
            |.|:.||:||::||       :...|.:.|..||||.|||:|||.:||.|..|||.|:|.|||||
  Rat   260 DHTDGVIKLRKDQL-------QNAGELEKVKKKRRLDFLDILLLARMENGDSLSDKDLRAEVDTF 317

  Fly   305 MFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEG-------REKESMPYLEAVIKETLRIY 362
            ||||||||:|.:::....|:.:|:.|||..||...:.|       ...:.:||....|||.||:|
  Rat   318 MFEGHDTTASGVSWIFYALATHPEHQQRCREEVQSVLGDGSSITWDHLDQIPYTTMCIKEALRLY 382

  Fly   363 PSVPFFSRKVLEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFA 425
            |.||...|::...:..  |: ::|||..::..||.||.:||.:|:||.|||.|| ..:...|..:
  Rat   383 PPVPGIVRELSTSVTFPDGR-SLPKGIQVTLSIYGLHHNPKVWPNPEVFDPSRF-APDSPRHSHS 445

  Fly   426 FAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRL 483
            |..||.|.|||||::|||.|:|..:|:.|..:..|||....|.||..||.||.|||.|
  Rat   446 FLPFSGGARNCIGKQFAMSEMKVIVALTLLRFELLPDPTKVPIPLPRLVLKSKNGIYL 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	158/479 (33%)
Cyp4a1	NP_787031.1	p450	52..503	CDD:278495	160/461 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348422
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750