DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and AgaP_AGAP012294

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_001238278.2	Gene:	AgaP_AGAP012294 / 4577529	VectorBaseID:	AGAP012294	Length:	538	Species:	Anopheles gambiae

Alignment Length:	582	Identity:	144/582 - (24%)
Similarity:	236/582 - (40%)	Gaps:	164/582 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LWAAFLRYLPKILNFLRLQRFAKTLPGP--TIGELIAN-----VKKGEILNWLKELREK--HGPV 66
            |..|...||.:..||.      |:.|.|  .:..|..:     :|:..:.::::...|:  :..:
Mosquito    14 LLVALYVYLTRNNNFF------KSFPIPCMEVEPLFGSHRKLLLKQISLHDFVRSCYERFPNAKI 72

  Fly    67 FRIWFGKDLMVMFTDPEDIKQL--------LGNNQLL----TKSRNYELLEPWLGKGLLTNGGES 119
            |.::.....|.:..|||.|||:        :.:..:|    :.|||..::   ..|.|....|:.
Mosquito    73 FGLFEMITPMFVVRDPELIKQITVKDFDHFVNHRAILPGDGSSSRNSSIM---FTKVLFNLNGQR 134

  Fly   120 WHRRRKLLTPGF-------HFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAI 177
            |...|..|:|.|       .|.::.|..|.|       ::.|.| ..|:.|::......|..|.|
Mosquito   135 WRNVRNTLSPAFTGSKMRQMFTMIVECSENM-------IKELAT-FTGQEFEVKNLFIRFTNDVI 191

  Fly   178 CETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKE--REAALKVLHD 240
            ...|.|::.:                         ||..:.|||:::   ||:  ....|||.
Mosquito   192 ASCAFGVRIN-------------------------SFRDKENVFYRY---GKDITNFGRLKVF-- 226

  Fly   241 ETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFL-------------------DML-LLTQ 285
                 :::...|||.:...|.    :.|:..:..:.|.                   ||: ||.|
Mosquito   227 -----LKMMGYQLIPKLMAWL----EIDIFDREHVQFFIDLFRQSVQEREQHGIVRPDMIHLLMQ 282

  Fly   286 MEGG-------------------------------AELSDTDIREEVDTFMFEGHDTTSSAIAFA 319
            ...|                               .:||:.::..:...|...|.|..:|.:.|.
Mosquito   283 ANNGKLRYQPTDHEEVEGFATAKESNDEKVVPEDMVKLSENEMVAQCLIFFLAGFDIIASVMTFL 347

  Fly   320 LSLLSKNPDVQQRAFEE----ASELEGRE-----KESMPYLEAVIKETLRIYPSVPFFSRKVLED 375
            |..::.:|::|||.:||    :..|:|:.     .::|.||:.|:.||||.:||.|...|...:|
Mosquito   348 LYEVALDPEIQQRLYEEIQQVSESLDGKSITYDALQNMRYLDMVVSETLRKWPSQPATDRLCNQD 412

  Fly   376 LEVGKLT------VPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPF---AFAAFSA 431
            .:|..:|      :|||..:|..|..||.||..:|||.||||:||  |::..|..   |:..|..
Mosquito   413 YKVTDVTPNVDIIIPKGCIVSIPIAGLHYDPAIYPDPTRFDPERF--NDENKHKIPLGAYLPFGL 475

  Fly   432 GPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELV-----TKSGNGIRLRILPR 488
            ||||||..:||::|:|..:..||.:|.| ...:..|.|| :|.     |.:..||.|::.||
Mosquito   476 GPRNCIASRFALMEVKAIVYQLLLNYEF-KRSERTPVPL-KLAKGFASTSAEKGIYLQLSPR 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	128/532 (24%)
AgaP_AGAP012294	XP_001238278.2	p450	41..532	CDD:278495	133/544 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910