DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4s3 and Cyp4d14

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001259179.1	Gene:	Cyp4d14 / 45706	FlyBaseID:	FBgn0023541	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	201/521 - (38%)
Similarity:	308/521 - (59%)	Gaps:	51/521 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LALVAFVLWAAFLRYLPKILNFLRLQRFAKT-----LPGPTIGELIANVKKGEILNWLKELREKH 63
            |.|.|.:|..|.      ..:::|.:|..|.     :.||....|:.|   ..:|  :.|..:..
  Fly     3 LELFAILLATAL------AWDYMRKRRHNKMYAEAGIRGPKSYPLVGN---APLL--INESPKSK 56

  Fly    64 GPVFRIW------FGKDLMV--------MFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLT 114
            ..:|.:.      |||::..        |..|.:.|:.::.:.|.:.|:..|.||..|||.|||.
  Fly    57 SSIFDMQFRLIAEFGKNIKTQMLGESGFMTADSKMIEAIMSSQQTIQKNNLYSLLVNWLGDGLLI 121

  Fly   115 NGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGES-FDIYPYITLFALDAIC 178
            :.|:.|.||||::||.|||:||.:|.|..::....:|::|..:|:|:: .:::|...|.|:|.|.
  Fly   122 SQGKKWFRRRKIITPAFHFKILEDFVEVFDQQSATMVQKLYDRADGKTVINMFPVACLCAMDIIA 186

  Fly   179 ETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFK--HTKPGKEREAALKVLHDE 241
            |||||:|.:||||....|||:|.:...::.::..:..|||:...|  :.|...:...|:|.:||.
  Fly   187 ETAMGVKINAQLQPQFTYVQSVTTASAMLAERFMNPLQRLDFTMKLFYPKLLDKLNDAVKNMHDF 251

  Fly   242 TNRVIRLRREQLIQERNEWKPEAEQ---DDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDT 303
            ||.||..||| |:|:......:|:.   :|||.|||:|.||:||.:.:: ||.||:.||||||||
  Fly   252 TNSVITERRE-LLQKAIADGGDADAALLNDVGQKRRMALLDVLLKSTID-GAPLSNDDIREEVDT 314

  Fly   304 FMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGREKES---------MPYLEAVIKETL 359
            |||||||||:|:|||...||:::|:||.|.|:|..::.|.:|.:         :.|||.||||:|
  Fly   315 FMFEGHDTTTSSIAFTCYLLARHPEVQARVFQEVRDVIGDDKSAPVTMKLLGELKYLECVIKESL 379

  Fly   360 RIYPSVPFFSRKVLEDLEV-GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEK-QMH 422
            |::||||...|.:.:|..: ||| :|..:::..|||...|||..|||||:|.||||.:..| ::.
  Fly   380 RLFPSVPIIGRYISQDTVLDGKL-IPADSNVIILIYHAQRDPDYFPDPEKFIPDRFSMERKGEIS 443

  Fly   423 PFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILP 487
            |||:..|||||||||||||||||:|::::.::|.:..|| ...:.:|:..::.:|..||...:.|
  Fly   444 PFAYTPFSAGPRNCIGQKFAMLEMKSTISKMVRHFELLP-LGEEVQPVLNVILRSTTGINCGLKP 507

  Fly   488 R 488
            |
  Fly   508 R 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	187/464 (40%)
Cyp4d14	NP_001259179.1	p450	34..489	CDD:278495	187/463 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460461
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.910