DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4c3

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_524598.1	Gene:	Cyp4c3 / 43663	FlyBaseID:	FBgn0015032	Length:	535	Species:	Drosophila melanogaster

Alignment Length:	504	Identity:	211/504 - (41%)
Similarity:	303/504 - (60%)	Gaps:	35/504 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 LPKILNFL--------RLQRFAKTLPGPT----IGELI-ANVKKGEILNWLKELREKHGP---VF 67
            |..||.||        ||.::.:.:|||.    :|..| .||...|:.|.:..:::..|.   :.
  Fly    34 LGSILIFLVVYNKRRSRLVKYIEKIPGPAAMPFLGNAIEMNVDHDELFNRVIGMQKLWGTRIGIN 98

  Fly    68 RIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKLLTPGFH 132
            |:|.|....|:..:||.::.:|.:.:.:.||.:|:.|.||||:||||:....||.|||:|||.||
  Fly    99 RVWQGTAPRVLLFEPETVEPILNSQKFVNKSHDYDYLHPWLGEGLLTSTDRKWHSRRKILTPAFH 163

  Fly   133 FRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMGIKKHAQLQSDSEYV 197
            |:||.:|.:...|...:|.|:|..:...|:|:::||:||..||.:||||||.:.:||..|:||||
  Fly   164 FKILDDFIDVFNEQSAVLARKLAVEVGSEAFNLFPYVTLCTLDIVCETAMGRRIYAQSNSESEYV 228

  Fly   198 QAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQL--IQERNEW 260
            :||..|..::..:....|.:.:..|..|...|..::.:..||..:|.|||.|:.:|  :||.|..
  Fly   229 KAVYGIGSIVQSRQAKIWLQSDFIFSLTAEYKLHQSYINTLHGFSNMVIRERKAELAILQENNNN 293

  Fly   261 K----PEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFALS 321
            .    |:| .||||.|:||||||:|:....| |..||:.||||||||||||||||||:||::.|.
  Fly   294 NNNNAPDA-YDDVGKKKRLAFLDLLIDASKE-GTVLSNEDIREEVDTFMFEGHDTTSAAISWTLF 356

  Fly   322 LLSKNPDVQQRAFEEASELEGREKES---------MPYLEAVIKETLRIYPSVPFFSRKVLEDLE 377
            ||..:|:.|:|..||...:.|.:||:         |.|||..||::||::||||..:|.|.||:.
  Fly   357 LLGCHPEYQERVVEELDSIFGDDKETPATMKNLMDMRYLECCIKDSLRLFPSVPMMARMVGEDVN 421

  Fly   378 VGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFL-VNEKQMHPFAFAAFSAGPRNCIGQKF 441
            :|...||.|.....:.|.|||:|:.||.||:|:||.|| .|....||||:..|||||||||||||
  Fly   422 IGGKIVPAGTQAIIMTYALHRNPRVFPKPEQFNPDNFLPENCAGRHPFAYIPFSAGPRNCIGQKF 486

  Fly   442 AMLELKTSLAMLLRSYRF-LPDKDHQPKPLAELVTKSGNGIRLRILPRD 489
            |:||.|..::.:||.|:. ..|:......|.||:.:..:|:|::|.|||
  Fly   487 AILEEKAVISTVLRKYKIEAVDRREDLTLLGELILRPKDGLRVKITPRD 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	195/458 (43%)
Cyp4c3	NP_524598.1	p450	59..531	CDD:278495	200/473 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453304
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.800