DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4a30b

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_006503285.1	Gene:	Cyp4a30b / 435802	MGIID:	3717145	Length:	510	Species:	Mus musculus

Alignment Length:	497	Identity:	165/497 - (33%)
Similarity:	261/497 - (52%)	Gaps:	28/497 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEILNWLKELREKHGP 65
            :|.|.|:..:|.:| ..||.:......||:|.   |.|....|..|..|.:.|..:....||...
Mouse    22 VSLLGLLLLLLKSA-QYYLHRQWLIKSLQQFP---PAPPPQWLFGNTLKDQDLQQILLCVEKFPS 82

  Fly    66 VFRIW-FGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKLLTP 129
            .:..| :|....|:..||:.:|.:||.:.... .|:|....||:|.|||...|:.|.:.|::|||
Mouse    83 TYVRWLWGNHARVVIYDPDYMKVILGRSDPKV-VRSYSFFAPWIGYGLLLLNGKKWFQHRRMLTP 146

  Fly   130 GFHFRILSEFKEPMEENCRILVRRLRTKANGE-SFDIYPYITLFALDAICETAMGIKKHAQLQ-- 191
            .||:.||..:...|.::..:::.:.....:.: ..:||..|:|..::.:.:.|...:...||:
Mouse   147 AFHYDILKPYVGIMVDSVHVMLDKWEQLVDQDCPLEIYQDISLMTMETMMKCAFSYQGSVQLEDC 211

  Fly   192 -SDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQLIQ 255
             :...|::||:.:..:::.:..:.:.:.|..:..:..|:....|.::.|..|.||||:|:.||
Mouse   212 RNSKSYIKAVEDLTHLIYLRVRNGFHQNNTIYSLSSNGRSFYHACQIAHKHTERVIRMRKAQL-- 274

  Fly   256 ERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFAL 320
                 :.|||.:....|:||.|||:||..|.|.|..|||.|:|.|:||||||||:||:|.|::..
Mouse   275 -----QNEAELEKFRKKKRLDFLDILLFAQTEDGKSLSDEDVRAEMDTFMFEGHNTTASGISWIF 334

  Fly   321 SLLSKNPDVQQRAFEEASELEG-------REKESMPYLEAVIKETLRIYPSVPFFSRKVLEDLEV 378
            ..|:.:|:.|||..||...:.|       ...:.|||....|||.||:||.:|..||::...:..
Mouse   335 YALATHPEHQQRCREEVKSILGNGTSVTLNHLDQMPYTTMCIKEALRLYPPIPGASRELSSPVTF 399

  Fly   379 -GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVN-EKQMHPFAFAAFSAGPRNCIGQKF 441
             ...::|||..::...|.||.:|:..|:.|.|||.||... .:|.|  ||..||||.|||||::|
Mouse   400 PDGCSLPKGFLVTLSFYGLHHNPRLRPNAEVFDPSRFAPGAPRQTH--AFLPFSAGTRNCIGKQF 462

  Fly   442 AMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRL 483
            .|.|||.::|:.|..:..|||....|..::::|.||.|||.|
Mouse   463 TMNELKVAVALTLLRFELLPDPTRVPILVSKIVLKSKNGIYL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	148/447 (33%)
Cyp4a30b	XP_006503285.1	p450	59..504	CDD:365848	152/454 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844981
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650