DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4s3 and Cyp313a4

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_650224.3	Gene:	Cyp313a4 / 41563	FlyBaseID:	FBgn0038076	Length:	494	Species:	Drosophila melanogaster

Alignment Length:	476	Identity:	137/476 - (28%)
Similarity:	229/476 - (48%)	Gaps:	49/476 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 FVLWAAFLRYLPKILNFLRLQRFAKTL--PGPTIGELIAN-----VKKGEILNWLKELREKHGPV 66
            |:||..||        :.|.:.:..||  ||| :|..|..     :::.:|||......:||||.
  Fly    12 FLLWIYFL--------WSRRRFYLLTLKIPGP-LGYPILGMAHWLMRREDILNAFGCFLDKHGPT 67

  Fly    67 FRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKLLTPGF 131
            ...|.|....::.:||:.::.:..:...:.|...|:.::...|.||.:.....|...||||.|.|
  Fly    68 IFSWLGPIPFMIVSDPQVVQDIFTSPHCVNKGIIYKAVDDGAGVGLFSLKDPRWSIHRKLLNPAF 132

  Fly   132 HFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMG--IKKHAQLQSDS 194
            ..::|..|.........:|:.:|....:....|:.|.:..|.|....:|.||  :|.....:|:|
  Fly   133 GHKVLLSFLPIFNRETALLLDQLEPLQDDGEKDLIPLLQSFTLGIATQTTMGSDVKDEESFRSNS 197

  Fly   195 EYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQLIQERNE 259
             .:...|.|...|....||.|  ||..|.....|||..      :.:....||....::|:.:
  Fly   198 -LLGRYQCILETMTDMCFSPW--LNSRFCRQLAGKESH------YYQAKTEIRQFIRKIIERK-- 251

  Fly   260 WKPEAEQDDVGAKRRLAFLD----MLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFAL 320
                ..:|::||...:...|    :.|:|.:......:..::.:|.:..:|...:||::|:.:.|
  Fly   252 ----LAEDEMGALPSIQSNDKNLFLNLVTDLMRRGVFTLKNVEDESNIIVFGAFETTANAVYYTL 312

  Fly   321 SLLSKNPDVQQRAFEEAS---------ELEGREKESMPYLEAVIKETLRIYPSVPFFSRKVLEDL 376
            .||:..|:.|:|||||..         ::...:.:.|.||:.::.|::|:.|.||..||:..:||
  Fly   313 MLLAMFPEYQERAFEEIKTIFPNTGDFDVSYADTQQMVYLDLILNESMRVIPPVPVVSRQTSQDL 377

  Fly   377 EVGK-LTVPKGASISCLIYMLHRDPKNF-PDPERFDPDRFLV-NEKQMHPFAFAAFSAGPRNCIG 438
            ::.. :.||||..|:..||.:||..|.: ||.|.|:||.||. |.:..||:|:..|:.|.|||||
  Fly   378 KLSNGIVVPKGVQIAIDIYHMHRSKKIWGPDAETFNPDHFLPHNIQDKHPYAYIPFTKGIRNCIG 442

  Fly   439 QKFAMLELKTSLAMLLRSYRF 459
            .::|::..|.:||.|||:|||
  Fly   443 WRYALISAKVTLAKLLRNYRF 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	130/450 (29%)
Cyp313a4	NP_650224.3	p450	33..465	CDD:299894	129/447 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.860