DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and CYP4F3

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_000887.2	Gene:	CYP4F3 / 4051	HGNCID:	2646	Length:	520	Species:	Homo sapiens

Alignment Length:	537	Identity:	189/537 - (35%)
Similarity:	279/537 - (51%)	Gaps:	69/537 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLALVAFVLW--------------AAFLRYLPKIL--------NFLRLQRFAKTLPGPT---- 39
            |..|:|.:..||              |::|  |.:||        |..||:.|    |.|.
Human     1 MPQLSLSSLGLWPMAASPWLLLLLVGASWL--LARILAWTYTFYDNCCRLRCF----PQPPKRNW 59

  Fly    40 -IGELIANVKKGEILNWLKELREKHGPVFRIWFGK-DLMVMFTDPEDIKQLL-GNNQLLTKSR-N 100
             :|.|.......|.|.:.:.|....|.:...|.|. ..:|....|..||.:| ....::.|.: .
Human    60 FLGHLGLIHSSEEGLLYTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKDKVF 124

  Fly   101 YELLEPWLGKGLLTNGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGES--F 163
            |..|:||||.|||.:.||.|.|.|::|||.|||.||..:.:...|:..|:..:.:..|:..|  .
Human   125 YSFLKPWLGDGLLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLASEGSARL 189

  Fly   164 DIYPYITLFALDAICETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPG 228
            |::.:|:|..||::.:.......|.| :..|||:.|:..:..::.|:.......::..:..|..|
Human   190 DMFEHISLMTLDSLQKCVFSFDSHCQ-EKPSEYIAAILELSALVTKRHQQILLYIDFLYYLTPDG 253

  Fly   229 KEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDD-VGAK---RRLAFLDMLLLTQMEGG 289
            :....|.:::||.|:.|        ||||....|....|| :.||   :.|.|:|:|||::.|.|
Human   254 QRFRRACRLVHDFTDAV--------IQERRRTLPSQGVDDFLQAKAKSKTLDFIDVLLLSKDEDG 310

  Fly   290 AELSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASEL----EGREKE---- 346
            .:|||.|||.|.|||||||||||:|.:::.|..|:|:|:.|:|..:|..||    |.:|.|
Human   311 KKLSDEDIRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQEVQELLKDREPKEIEWDDL 375

  Fly   347 -SMPYLEAVIKETLRIYPSVPFFSRKVLEDLEV--GKLTVPKGASISCLI--YMLHRDPKNFPDP 406
             .:|:|...|||:||::|.||..||...:|:.:  |:: :|||  |.|||  :..|.:|..:|||
Human   376 AQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLPDGRV-IPKG--IICLISVFGTHHNPAVWPDP 437

  Fly   407 ERFDPDRF-LVNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPL 470
            |.:||.|| ..|.|:..|.||..|||||||||||.|||.|:|..|.:.|..:|.|||.. :|:..
Human   438 EVYDPFRFDPKNIKERSPLAFIPFSAGPRNCIGQAFAMAEMKVVLGLTLLRFRVLPDHT-EPRRK 501

  Fly   471 AELVTKSGNGIRLRILP 487
            .|||.::..|:.||:.|
Human   502 PELVLRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	168/461 (36%)
CYP4F3	NP_000887.2	p450	52..515	CDD:365848	172/475 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154687
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.650