DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4s3 and Cyp312a1

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001262008.1	Gene:	Cyp312a1 / 40005	FlyBaseID:	FBgn0036778	Length:	510	Species:	Drosophila melanogaster

Alignment Length:	492	Identity:	169/492 - (34%)
Similarity:	261/492 - (53%)	Gaps:	42/492 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPT----IGEL--IANV-------KKGEILNW 55
            |||..::|: .|.|.       .|:.|.....|.|.    ||.|  :|.:       :..|::|
  Fly    11 LALSLYLLY-VFERQ-------SRIDRLTHKWPAPPALPFIGHLHILAKLVGPHPLRRATEMIN- 66

  Fly    56 LKELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESW 120
                ...|....::|.|..|.::..:|:||:.|....|||.|:.:|.:.|.||.:||.|:|.|.|
  Fly    67 ----EHLHDHRAKLWMGTKLYLVDCNPKDIQALCSAQQLLQKTNDYRVFENWLCEGLFTSGFEKW 127

  Fly   121 HRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKA-NGESFDIYPYITLFALDAICETAMGI 184
            ..|||::.|.|::.::.:|....|:..|||:..:...| :|:..|....|:.|.||.|||||:|:
  Fly   128 SHRRKIVMPAFNYTMIKQFVAVFEKQSRILLTNVAKFAESGDQIDFLQLISCFTLDTICETALGV 192

  Fly   185 KKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLR 249
            ...:|..:.|||:.||:||..::.|:..:.:.|.:..||.|...|..:..:|.||..|..:|:.|
  Fly   193 SVGSQSSAKSEYLDAVKSILVIIDKRLKNIFYRNSFIFKRTSHYKREQELIKTLHGFTEGIIQKR 257

  Fly   250 REQLIQE---RNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDT 311
            .:::.|:   ||....:||.|  |.||.|.|||.|||::...|..|:..||||||||.:|.|.|.
  Fly   258 IDEINQDAENRNYQSSDAELD--GVKRTLCFLDTLLLSKGPDGKPLTVKDIREEVDTIIFGGFDL 320

  Fly   312 TSSAIAFALSLLSKNPDVQQRAFEEASELEGREK---------ESMPYLEAVIKETLRIYPSVPF 367
            |::.:.|.:..::.:|:.|||..||...:.|::|         ..:.:|||.||||||:|||.|.
  Fly   321 TATTLNFFMYNMTLHPEHQQRCREEVWSVCGKDKSEPISIEQVRQLEFLEACIKETLRMYPSGPL 385

  Fly   368 FSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVN-EKQMHPFAFAAFSA 431
            .:||...:..:....:|||:.:......:.|....||||..|.|||:.:. |.::....|..|.|
  Fly   386 TARKATANCTINDFFIPKGSDVIISPIYMGRCKDFFPDPMVFKPDRWAIGAEPKIEATTFIPFMA 450

  Fly   432 GPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPK 468
            |.|:|:||::||:.||..||.|||::.|.|..:.|.|
  Fly   451 GARSCMGQRYAMVMLKMVLAHLLRNFLFEPLGERQVK 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	161/461 (35%)
Cyp312a1	NP_001262008.1	p450	35..505	CDD:278495	161/460 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460460
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	8.890