DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4s3 and Cyp4d8

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_523961.2	Gene:	Cyp4d8 / 38841	FlyBaseID:	FBgn0015033	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	197/513 - (38%)
Similarity:	295/513 - (57%)	Gaps:	30/513 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEILN---WLKELRE- 61
            |....||..:..|.::.:|.:    ...:|....||||....||..::....||   ::|..||
  Fly     1 MLLFLLVVLLFGAGWIIHLGQ----ADRRRKVANLPGPICPPLIGAMQLMLRLNPKTFIKVGREY 61

  Fly    62 --KHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRR 124
              |.|.:.|:|....|::|..|.|..:|||.:.:.|.|...|::|..|||.|||.:.|:.||:||
  Fly    62 VLKFGHLQRVWIFNRLLIMSGDAELNEQLLSSQEHLVKHPVYKVLGQWLGNGLLLSDGKVWHQRR 126

  Fly   125 KLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMGIKKHAQ 189
            |::||.|||.||.:|.|..::...|.|:||..||||.:||:|..|...|||.|.|||||.|.:||
  Fly   127 KIITPTFHFSILEQFVEVFDQQSNICVQRLAQKANGNTFDVYRSICAAALDIIAETAMGTKIYAQ 191

  Fly   190 LQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPG-KEREAAL-KVLHDETNRVIRLRREQ 252
            ....:.|.:||.....::..:..|.:.::.:.|..|.|. |.|:..| :.:.:.|.:||..||:.
  Fly   192 ANESTPYAEAVNECTALLSWRFMSVYLQVELLFTLTHPHLKWRQTQLIRTMQEFTIKVIEKRRQA 256

  Fly   253 LIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIA 317
            |..::::....|: :|||:|||:|.||:||::.:: |..|::.:||||||||||||||||:||::
  Fly   257 LEDQQSKLMDTAD-EDVGSKRRMALLDVLLMSTVD-GRPLTNDEIREEVDTFMFEGHDTTTSALS 319

  Fly   318 FALSLLSKNPDVQQRAFEEASELEG---------REKESMPYLEAVIKETLRIYPSVPFFSRKVL 373
            |.|..||::|:||.:..||..::.|         |:...:.|:|.||||:||:||.||...||:.
  Fly   320 FCLHELSRHPEVQAKMLEEIVQVLGTDRSRPVSIRDLGELKYMECVIKESLRMYPPVPIVGRKLQ 384

  Fly   374 EDLEV-----GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGP 433
            .|.:.     |...:|.|:.|...|:.:||.|:.||:|:.|.|:|. .|..::.||....|||||
  Fly   385 TDFKYTHSVHGDGVIPAGSEIIIGIFGVHRQPETFPNPDEFIPERH-ENGSRVAPFKMIPFSAGP 448

  Fly   434 RNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILPRDEN 491
            |||||||||.||:|..||.::|.|..|| ...:.:.:..:|.:|..|.:|.:..|..|
  Fly   449 RNCIGQKFAQLEMKMMLAKIVREYELLP-MGQRVECIVNIVLRSETGFQLGMRKRKHN 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	185/455 (41%)
Cyp4d8	NP_523961.2	CYP4	66..497	CDD:410721	176/434 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460457
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.910