DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and cyp4t8

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_954686.2	Gene:	cyp4t8 / 387527	ZFINID:	ZDB-GENE-031219-3	Length:	509	Species:	Danio rerio

Alignment Length:	508	Identity:	183/508 - (36%)
Similarity:	275/508 - (54%)	Gaps:	58/508 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 FLRYLPKILNFLRLQR-FAKTL---PGPTIGELIANVKK--------GEILNWLKELREKHGPVF 67
            ||..|..::..|.::| ..||:   |||....|..:||:        .:|:.|:    |.:...|
Zfish    21 FLACLLTVVKLLIVRRKGVKTMERFPGPPAHWLFGHVKEFRQDGHDLEKIVKWM----ELYQFAF 81

  Fly    68 RIWFGKDLMVM-FTDPEDIKQLLGNNQLLTKSRN---YELLEPWLGKGLLTNGGESWHRRRKLLT 128
            .:|||..|.|: ...|..:|.:|    ..|:.::   |:...||||.|||.:.|:.|.|.|:|||
Zfish    82 PLWFGPSLAVLNIHHPSYVKTIL----TTTEPKDDYAYKFFIPWLGDGLLVSTGQKWFRHRRLLT 142

  Fly   129 PGFHFRILSEFKEPMEENCRILVRRLRTKANG-ESFDIYPYITLFALDAICETAMGIKKHAQLQS 192
            ||||:.:|..:.:.:.::.::::.:....:.. |||:::.:::|..||:|.:.|.....:.|..|
Zfish   143 PGFHYDVLKPYVKLISDSTKVMLDKWEVHSRSEESFELFKHVSLMTLDSIMKCAFSCNSNCQTDS 207

  Fly   193 DSE-YVQAVQSICRVMHKQSFSFWQRLNVFFKHTKP-------GKEREAALKVLHDETNRVIRLR 249
            .:. |:|||..:|.:::       .|..||..|:|.       |.....|..:.|:.|..|||.|
Zfish   208 GTNPYIQAVFDLCHLVN-------LRFRVFPYHSKAIFHLSPHGYRFRKAASIAHNHTAEVIRKR 265

  Fly   250 REQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSS 314
            :|.|       |.|.||..|..:|.|.|||:||..:.|....|||.|||.|||||||||||||:|
Zfish   266 KEVL-------KMEEEQGIVKNRRYLDFLDILLSARDEHQQGLSDEDIRAEVDTFMFEGHDTTAS 323

  Fly   315 AIAFALSLLSKNPDVQ-------QRAFEEASELEGREKESMPYLEAVIKETLRIYPSVPFFSRKV 372
            .|::....|:.||:.|       |:|.:..:.||..:...:||....|||:||::|.||..|||:
Zfish   324 GISWIFYNLACNPEHQEKCRQEIQQALDGKATLEWEDLNKIPYTTMCIKESLRLHPPVPGISRKL 388

  Fly   373 LEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFL-VNEKQMHPFAFAAFSAGPR 434
            .:.|..  |: |||:|.:|...||.:|.:...:.:|.:|||.||| .|.....|.||..||||||
Zfish   389 TKPLTFFDGR-TVPEGCTIGVSIYGIHMNSTVWENPYKFDPLRFLPENVANRSPHAFVPFSAGPR 452

  Fly   435 NCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILP 487
            |||||.|||.|:|.::|:.|:.|..:.|.||.||.:.::|.:|.|||.::|.|
Zfish   453 NCIGQNFAMNEMKVAVALTLKRYYLIKDPDHTPKMIPQVVLRSLNGIHIKIKP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	168/467 (36%)
cyp4t8	NP_954686.2	p450	46..501	CDD:306555	174/477 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.720