DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp6a8

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_523749.2	Gene:	Cyp6a8 / 36666	FlyBaseID:	FBgn0013772	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	527	Identity:	129/527 - (24%)
Similarity:	205/527 - (38%)	Gaps:	81/527 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIG---ELIANVKKGEIL-NWLKELREKHGPVF 67
            ||..|.|....|:.:.|.:.:.:......|....|   ||.......||. :...:.||...|..
  Fly    10 VAVALLAILTYYIHRKLTYFKRRGIPFVAPHLIRGNMEELQKTKNIHEIFQDHYNKFRESKAPFV 74

  Fly    68 RIWFGKDLMVMFTDPEDIKQLL--GNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKLLTPG 130
            ..:|.:.......|.|..||:|  ..:....|...|...:..:...|....|..|...|..|:..
  Fly    75 GFFFFQSPAAFVIDLELAKQILIKDFSNFSNKGIFYNEKDDPISAHLFNLDGAQWRLLRNKLSST 139

  Fly   131 FH-----------FRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMGI 184
            |.           ..:.:||...|.|..          ......:|...:..|.:|.|...|.||
  Fly   140 FTSGKMKLMYPTVVSVANEFMTVMHEKV----------PKNSVLEIRDLVARFTVDVIGTCAFGI 194

  Fly   185 KKHAQLQSDSEYVQ-AVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRL 248
            :.::.....:|::. ..:|:....|      ...||.|.: :.|...|:..:            :
  Fly   195 QCNSLRDEKAEFLYFGKRSLVDKRH------GTLLNGFMR-SYPKLARKLGM------------V 240

  Fly   249 RREQLIQE-----RNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDI-----REEV-- 301
            |....|||     ..|.....|::.:   :|..|:|||:..:.:....|.:.|:     .|||
  Fly   241 RTAPHIQEFYSRIVTETVAVREKEHI---KRNDFMDMLIELKNQKEMTLENGDVVRGLTMEEVLA 302

  Fly   302 DTFMF--EGHDTTSSAIAFALSLLSKNPDVQQRAFEEASE-LEGREK-------ESMPYLEAVIK 356
            ..|:|  .|.:|:||.:.|||..|:||||:|.:...|..| :|..::       :.:.||..|:.
  Fly   303 QAFVFFIAGFETSSSTMGFALYELAKNPDIQDKVRAEVEEVIEQHDQNFTYECTKDLKYLNQVLD 367

  Fly   357 ETLRIYPSVPFFSRKVLEDLEV---GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNE 418
            ||||:|..||...|...:...|   ....:..|.|:......:|.||..:|:|..|.|:||...|
  Fly   368 ETLRLYTIVPNLDRMAAKRYVVPGHPNFVIEAGQSVIIPSSAIHHDPSIYPEPFEFRPERFSPEE 432

  Fly   419 KQMHP-FAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLA----ELVTKSG 478
            ....| .|:..|..|||||||.:|..::.:..||:|:|:::| ......|.||.    ..|....
  Fly   433 SAGRPSVAWLPFGDGPRNCIGLRFGQMQARIGLALLIRNFKF-STCSKTPNPLVYDPKSFVLGVK 496

  Fly   479 NGIRLRI 485
            :||.|::
  Fly   497 DGIYLKV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	117/477 (25%)
Cyp6a8	NP_523749.2	p450	39..503	CDD:278495	123/496 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810