DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp6a14

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	548	Identity:	141/548 - (25%)
Similarity:	235/548 - (42%)	Gaps:	110/548 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 TLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEILNWLKELREK---HG 64
            |:|||..||..|:..:: ||.::.:.:......|.|.:|.:...|||....:..:.:.:|   .|
  Fly     4 TIALVGVVLGLAYSLHI-KIFSYWKRKGVPHETPLPIVGNMRGIVKKYHFRDINQRIYKKFKGQG 67

  Fly    65 PVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTN-------------G 116
            |:..::.......:.||.:.||      |::.|..:|     :..:|..||             .
  Fly    68 PIAGMYMFFKRTALITDLDFIK------QVMIKDFSY-----FQDRGAFTNPRDDPLTGHLFALE 121

  Fly   117 GESWHRRRKLLTPGFHFRILSEFKEPMEENCRILV---RRL---------RTKANGESFDIYPYI 169
            ||.|...|..|||.|       ....:::..:::|   .||         ..|....:.:|....
  Fly   122 GEEWRAMRHKLTPVF-------TSGKIKQMSKVIVDVGLRLGDAMDKAVKEAKVEEGNVEIKDLC 179

  Fly   170 TLFALDAICETAMGIKKHAQLQSDSEYVQAVQSI-CRVMHK---QSFSFWQRLNVFFKHTKPGKE 230
            ..|..|.|...|.|::.::.....:|:.|..:.| .|..|.   |||.|          |.....
  Fly   180 ARFTTDVIGSCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSFIF----------TNARLA 234

  Fly   231 REAALKVLHDETNRVIR--------------LRREQLIQERNEWKPEAEQDDVGAKRRLAFLDM- 280
            |:..:|||.|:..:...              ::|...|::..|.:.|   |...||:... :|:
  Fly   235 RKLRIKVLPDDLTQFFMSTVKNTVDYRLKNGIKRNDFIEQMIELRAE---DQEAAKKGQG-IDLS 295

  Fly   281 --LLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEE----ASE 339
              |.|.||...|.:           |...|.:|:||.::..|..|:..||:|||..||    .:.
  Fly   296 HGLTLEQMAAQAFV-----------FFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLAN 349

  Fly   340 LEGREKE-----SMPYLEAVIKETLRIYPSVPFFSRKVLEDLEV--GKLTVPKGASISCLIYMLH 397
            ::|.|..     .|.||:.|:.||||.:|.:|...|:..:|.::  ..:.:.||......::.:|
  Fly   350 VDGGELNYDVLAQMTYLDQVLSETLRKHPLLPHLIRETTKDYQIPNSDIVLDKGILALIPVHNIH 414

  Fly   398 RDPKNFPDPERFDPDRFLVNE-KQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRF-L 460
            .||:.:|:||:|||.||...| |..||.|:..|..|||||||.:|..::.|..|..|||.::| :
  Fly   415 HDPEIYPEPEKFDPSRFDPEEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSV 479

  Fly   461 PDKDHQPKPLAE---LVTKSGNGIRLRI 485
            .::...|...::   |:| :.:||.|::
  Fly   480 SNRTDVPLIFSKKSFLLT-TNDGIYLKV 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	127/495 (26%)
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	132/517 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810