DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4s3 and Cyp4e2

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001286196.1	Gene:	Cyp4e2 / 35822	FlyBaseID:	FBgn0014469	Length:	526	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	181/531 - (34%)
Similarity:	273/531 - (51%)	Gaps:	64/531 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKK-----GEILNWLKELREKH 63
            |.|||::..:.|           |.:|......||....|:.|..:     .|||:.:.....::
  Fly    13 LLLVAYLELSTF-----------RRRRVLNKFNGPRGLPLMGNAHQMGKNPSEILDTVFSWWHQY 66

  Fly    64 G-PVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKLL 127
            | ..|..|.|....|:.|..:.::.:|.:..|:|||..|:|..||||.||||:.|..||:.||::
  Fly    67 GKDNFVFWIGTYSNVLVTSSKYLEFILSSQTLITKSDIYQLTHPWLGLGLLTSTGSKWHKHRKMI 131

  Fly   128 TPGFHFRILSEFKEPMEENCRILVRRLRTKANGES-FDIYPYITLFALDAICETAMGIKKHAQLQ 191
            ||.|||.||.:|.|.|.||....::.|:|.|.|:: ||.........||.||:||||:..:|...
  Fly   132 TPAFHFNILQDFHEVMNENSTKFIKHLKTVAAGDNIFDFQEQAHYLTLDVICDTAMGVSINAMEN 196

  Fly   192 SDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQLIQE 256
            ..|..|||.:.:|..::.::|...:|..:.::...........||.|.|.||.:|..|    |:.
  Fly   197 RSSSIVQAFKDMCYNINMRAFHPLKRNELLYRLAPDYPAYSRTLKTLQDFTNEIIAKR----IEA 257

  Fly   257 RNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFALS 321
            ...........|...::::||||.||.:.:: |..|:..::.|||.||||||||||:|.::||:.
  Fly   258 HKSGAVSTNAGDEFTRKKMAFLDTLLSSTID-GRPLNSKELYEEVSTFMFEGHDTTTSGVSFAVY 321

  Fly   322 LLSKNPDVQQRAFEEASELEG----------REKESMPYLEAVIKETLRIYPSVPFFSRKVLEDL 376
            |||::.|.|::.|:|..|:.|          :|...|.||:..|||..|:||||||..|...:|.
  Fly   322 LLSRHQDEQRKLFKEQREVMGNSELGRDATFQEISQMKYLDLFIKEAQRVYPSVPFIGRFTEKDY 386

  Fly   377 EVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGPRNCIGQKF 441
            .:....||||.:::..:.||..:.|.|.||.:|.|:||.:  ::..||.:..|||||||||||||
  Fly   387 VIDGDLVPKGTTLNLGLVMLGYNEKVFKDPHKFRPERFEL--EKPGPFEYVPFSAGPRNCIGQKF 449

  Fly   442 AMLELKTSLAMLLRSYRFLPDKD---------------------------HQPKPL--AELVTKS 477
            |:||:||.::.::|::..||..|                           |:..|:  |.|..||
  Fly   450 ALLEIKTVVSKIIRNFEVLPALDELVSKDGYISTTIGLPDAERKKRDPYRHKYDPILSAVLTLKS 514

  Fly   478 GNGIRLRILPR 488
            .||:.:|:..|
  Fly   515 ENGLYIRLKER 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	165/477 (35%)
Cyp4e2	NP_001286196.1	p450	35..469	CDD:278495	161/440 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460462
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.800