DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4ad1

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_610380.1	Gene:	Cyp4ad1 / 35821	FlyBaseID:	FBgn0033292	Length:	516	Species:	Drosophila melanogaster

Alignment Length:	527	Identity:	166/527 - (31%)
Similarity:	257/527 - (48%)	Gaps:	55/527 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LALVAFVLWAAFLRYLPKILNFL-RLQRFAKTLPGPT----IGELIA-NVKKGE----ILNWLKE 58
            |..:|.:|....:....:|.|:: .:....:.:||||    :|.|.. .:|..|    :|.:.::
  Fly     3 LIAIAIILATILVFKGVRIFNYIDHMAGIMEMIPGPTPYPFVGNLFQFGLKPAEYPKKVLQYCRK 67

  Fly    59 LREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRR 123
            . :..|  ||........:|.:||.:|:.:|.::.||.|...|..|.||||.||||:.|..|.:.
  Fly    68 Y-DFQG--FRSLVFLQYHMMLSDPAEIQNILSSSSLLYKEHLYSFLRPWLGDGLLTSSGARWLKH 129

  Fly   124 RKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKAN-GESFDIYPYITLFALDAICETAMGIKKH 187
            :||..|.|....:..:...:.......|::|...:: .|.||....:....||.:||.|.|....
  Fly   130 QKLYAPAFERSAIEGYLRVVHRTGGQFVQKLDVLSDTQEVFDAQELVAKCTLDIVCENATGQDSS 194

  Fly   188 AQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQ 252
            :.....|:...|::.:|.|:.:::||..:|.:..|:.|....::..||.:|..|.||:|..||.|
  Fly   195 SLNGETSDLHGAIKDLCDVVQERTFSIVKRFDALFRLTSYYMKQRRALSLLRSELNRIISQRRHQ 259

  Fly   253 LIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIA 317
            |..|..     .:|   |......|||:||..:::|.. |.:.:|.|||.||:|.|||..::||:
  Fly   260 LAAENT-----CQQ---GQPINKPFLDVLLTAKLDGKV-LKEREIIEEVSTFIFTGHDPIAAAIS 315

  Fly   318 FALSLLSKNPDVQQRAFEE---------ASELEGREKESMPYLEAVIKETLRIYPSVPFFSRKVL 373
            |.|..||::.::||:|.||         |.|.:....:.|.|||.:|:||||:|||||..:|...
  Fly   316 FTLYTLSRHSEIQQKAAEEQRRIFGENFAGEADLARLDQMHYLELIIRETLRLYPSVPLIARTNR 380

  Fly   374 EDLEVGKLTVPKGAS-ISCLIYMLHRDPKNFPDPERFDPDRF--LVNEKQMHPFAFAAFSAGPRN 435
            ..:::....|.|..: |.|||.|.:.: |.|.||..|.|:||  ......:..|....||||||.
  Fly   381 NPIDINGTKVAKCTTVIMCLIAMGYNE-KYFDDPCTFRPERFENPTGNVGIEAFKSVPFSAGPRR 444

  Fly   436 CIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPK-----------PLAE--------LVTKSGNGI 481
            ||.:||||.::|..|:.|||.:..||..|..|.           |.:|        :..||.|||
  Fly   445 CIAEKFAMYQMKALLSQLLRRFEILPAVDGLPPGINDHSREDCVPQSEYDPVLNIRVTLKSENGI 509

  Fly   482 RLRILPR 488
            ::|:..|
  Fly   510 QIRLRKR 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	152/466 (33%)
Cyp4ad1	NP_610380.1	p450	36..470	CDD:278495	148/446 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460459
Domainoid	1	1.000	101	1.000	Domainoid score	I1781
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	11	10.800