DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4s3 and Cyp9b2

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_523646.1	Gene:	Cyp9b2 / 35635	FlyBaseID:	FBgn0015039	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	555	Identity:	133/555 - (23%)
Similarity:	222/555 - (40%)	Gaps:	130/555 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LALVAFVLW----AAFLRYLPKILNFLRLQRFAKTLPGPTIGEL-IANVKKGEILNWLKELREK- 62
            |.::.::::    |.|..:..:.|.|.:        |.|.:|.: .|.::|......|.|..|:
  Fly    10 LVVIGYLIYKWSTATFKTFEERKLYFEK--------PYPFVGNMAAAALQKSSFQRQLTEFYERT 66

  Fly    63 --HGPV--FRIWFGKDLMVMFTDPEDIKQL-------LGNNQLLTKSRNYELLEPWLGKGLLTNG 116
              |..|  |.:   :..|:...|||.||::       ..|:|....| |..|....|.    ...
  Fly    67 RQHKLVGFFNM---RTPMITLNDPELIKKVCVKDFDHFPNHQPFITS-NDRLFNDMLS----VMR 123

  Fly   117 GESWHRRRKLLTPGF-------HFRILSE-FKE---PMEENCRILVRRLRTKANGESFDIYPYIT 170
            .:.|...|..|||.|       .|.:::| |.|   .::.:.:.|..|     .|...|:.....
  Fly   124 DQRWKHMRNTLTPVFTAAKMRNMFTLMNESFAECLQHLDSSSKTLPGR-----KGFEVDMKVMCN 183

  Fly   171 LFALDAICETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFW-----------QRLNVFFKH 224
            ..:.|.|..||.|:|.::.....:|:.:..||:......|.|.|.           .:|.:|
  Fly   184 KLSNDIIATTAFGLKVNSYDNPKNEFYEIGQSLVFSRGLQFFKFMLSTLVPKLFSLLKLTIF--- 245

  Fly   225 TKPGKEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGG 289
                    .:.||  |...|:: :...|..::.|..:|:             .:.:|:..:.|..
  Fly   246 --------DSAKV--DYFARLV-VEAMQYREKHNITRPD-------------MIQLLMEAKNESE 286

  Fly   290 AELSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASE----LEGR-----EK 345
            .:.:|.:|..:...|.|...:..|:.|......|..|||||:|.:||..|    |.|.     ..
  Fly   287 DKWTDDEIVAQCFIFFFAAFENNSNLICTTTYELLYNPDVQERLYEEIVETKKALNGAPLTYDAV 351

  Fly   346 ESMPYLEAVIKETLRIYPSVPFFSR-------------KVLEDLEVG-KLTVPKGASISCLIYML 396
            :.|.|::.||.|:||.:.......|             ..|.|.:|| ::.:|        |..|
  Fly   352 QKMTYMDMVISESLRKWTLAAATDRLCSKDYTLTDDDGTKLFDFKVGDRINIP--------ISGL 408

  Fly   397 HRDPKNFPDPERFDPDRFLVNEK-QMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFL 460
            |.|.:.||:|.:||||||....| .|.|:.:..|..|||||||.::|::::|..|..||..|:.
  Fly   409 HLDDRYFPEPRKFDPDRFSEERKGDMVPYTYLPFGVGPRNCIGNRYALMQVKGMLFNLLLHYKI- 472

  Fly   461 PDKDHQPKPLAEL-VTKSG------NGIRLRILPR 488
               :..|:.:.:| .:.||      :|..:.::||
  Fly   473 ---EASPRTIKDLWGSASGFNFTPRSGFWMHLVPR 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	122/492 (25%)
Cyp9b2	NP_523646.1	p450	37..478	CDD:299894	122/500 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810