DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp6a2

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	539	Identity:	129/539 - (23%)
Similarity:	223/539 - (41%)	Gaps:	102/539 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEIL-----NWLKELREKHGP 65
            |:|.....|:|.:  :..|:...:......|.|..|.:: ..:|..::     ::..:.|:...|
  Fly     8 LIAISSLLAYLYH--RNFNYWNRRGVPHDAPHPLYGNMV-GFRKNRVMHDFFYDYYNKYRKSGFP 69

  Fly    66 VFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNG-------------G 117
            ....:|.........|.:     |..|.|:....|:      ..:|...||             |
  Fly    70 FVGFYFLHKPAAFIVDTQ-----LAKNILIKDFSNF------ADRGQFHNGRDDPLTQHLFNLDG 123

  Fly   118 ESWHRRRKLLTPGF-----HFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAI 177
            :.|...|:.|||.|     .|...:..| ..||..:::..::....||...:|...:..|..|.|
  Fly   124 KKWKDMRQRLTPTFTSGKMKFMFPTVIK-VSEEFVKVITEQVPAAQNGAVLEIKELMARFTTDVI 187

  Fly   178 CETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQ--RLNVFFKHTKPGKEREAALKVLHD 240
            ...|.||:.:......|::        |.|.::.|:..:  :|...|..:.|.......::::.:
  Fly   188 GTCAFGIECNTLRTPVSDF--------RTMGQKVFTDMRHGKLLTMFVFSFPKLASRLRMRMMPE 244

  Fly   241 ETNR-VIRLRREQL-IQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVD- 302
            :.:: .:||..:.: ::||..:|            |..|:::|:..:.:|...|.:.::.|.:|
  Fly   245 DVHQFFMRLVNDTIALRERENFK------------RNDFMNLLIELKQKGRVTLDNGEVIEGMDI 297

  Fly   303 --------TFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEE----ASELEGR----EKESMPYL 351
                    .|...|.:|:||.:::.|..|::|.|:|.|...|    ..|.||:    ..::|.||
  Fly   298 GELAAQVFVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEIQTVLEEQEGQLTYESIKAMTYL 362

  Fly   352 EAVIKETLRIYPSVPFFSRKVLEDLEV---GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDR 413
            ..||.||||:|..||...||.|.|..|   .||.:.||..:.......|||...:|:||.|||:|
  Fly   363 NQVISETLRLYTLVPHLERKALNDYVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPER 427

  Fly   414 FLVNEKQMHPFAFAA--------FSAGPRNCIGQKFAMLELKTSLAMLLRSYRF-LPDKDHQP-- 467
            |       .|...||        |..|||||||.:|..::.:..||.::..:|. :.|....|
  Fly   428 F-------SPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLK 485

  Fly   468 -KPLAELVTKSGNGIRLRI 485
             .|:: :|..:..||.||:
  Fly   486 YSPMS-IVLGTVGGIYLRV 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	118/492 (24%)
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	122/506 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810