DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp11b3

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_861545.1	Gene:	Cyp11b3 / 353498	RGDID:	727886	Length:	498	Species:	Rattus norvegicus

Alignment Length:	485	Identity:	107/485 - (22%)
Similarity:	187/485 - (38%)	Gaps:	105/485 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 ELIANVKKGEILNWLKELREKH---------------GPVFRIWFGKDLMVMFTDPEDIKQLLGN 91
            |.|....:.:.|..::.|||:.               ||:||...|...:|....|||.::|...
  Rat    38 EAIPQYSRNKWLKMIQILREQSQENLHLEMHQAFQELGPIFRHSAGGAQIVSVMLPEDAEKLHQV 102

  Fly    92 NQLLTKSRNYELLEPW--------LGKGLLTNGGESWHRRRKLLTPG------------FHFRIL 136
            ..:|.:...   ||.|        |.:|:....|..|...|..|.|.            |...:.
  Rat   103 ESILPRRMT---LESWVAHRELRGLRRGVFLLNGADWRFNRLQLNPNMLSPKAVQSFVPFVDVVA 164

  Fly   137 SEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDA----ICETAMGIKKHAQLQSDSEYV 197
            .:|.|.:::      |.|.......|.||...:..:.::|    |....:|:..|.......:::
  Rat   165 RDFVENLKK------RMLENVHGSMSMDIQSNVFNYTMEASHFVISGERLGLTGHDLNPESLKFI 223

  Fly   198 QAVQSICR-----VMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQLIQER 257
            .|:.|:.:     :...::.:.|....|:..|.:       :..::.:...:.|:....:|.:.|
  Rat   224 HALHSMFKSTTQLMFLPKNLTRWTSTQVWKGHFE-------SWDIISEYVTKCIKNVYRELAEGR 281

  Fly   258 NE-WKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFALS 321
            .: |.                    ::::|...:.||...|.......:....|||:.::...|.
  Rat   282 QQSWS--------------------VISEMVAQSTLSMDAIHANSMELIAGSVDTTAISLVMTLF 326

  Fly   322 LLSKNPDVQQRAFEEASELEG-------REKESMPYLEAVIKETLRIYPSVPFFSRKVLEDLEVG 379
            .|::||||||...:|:...|.       :....:|.|.|.:|||||:||......|.|..||.:.
  Rat   327 ELARNPDVQQALRQESLAAEASIAANPQKAMSDLPLLRAALKETLRLYPIGSSLERIVDSDLVLQ 391

  Fly   380 KLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGPRNCIGQKFAML 444
            ...||.|..:...:|.:.|:|..||.|||:.|.|:|..::.   |...||..|.|.|:|::.|.:
  Rat   392 NYHVPAGTLVIIYLYSMGRNPAVFPRPERYMPQRWLERKRS---FQHLAFGFGVRQCLGRRLAEV 453

  Fly   445 ELKTSLAMLLR--------------SYRFL 460
            |:...|..:|:              :|||:
  Rat   454 EVLLLLHHMLKIFQVETLRQEDVQMAYRFV 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	107/485 (22%)
Cyp11b3	NP_861545.1	p450	41..494	CDD:278495	105/482 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910