Protein Alignment Cyp4s3 and Cyp3a44

DIOPT Version :10

• Sequence 1: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_796354.1
• Gene: Cyp3a44 / 337924
• MGIID: 2449818
• Length: 504
• Species: Mus musculus
• Alignment Length: 527
• Identity: 138/527 - (26%)
• Similarity: 245/527 - (46%)
• Gaps: 75/527 - (14%)

  Fly     1 MSTLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEILNWLKELREKHGP 65
            :.||.|:|.:| ....||..:.....:.|......|.|.:|.:: |...| |..:..|..||:|.
Mouse     9 LDTLVLLAIIL-VLLYRYGTRTHGLFKKQGIPGPKPLPFLGTVL-NYYTG-IWKFDMECYEKYGK 70

  Fly    66 VFRIWFGKDLMVMFTDPEDIKQLLGNN--QLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKLLT 128
            .:.::.|:..:::.||||.||.:|..:  .:.|..|.:..: ..:.|.:..:..|.|.|.|.||:
Mouse    71 TWGLFDGQTPLLVITDPETIKNVLVKDCLSVFTNRREFGPV-GIMSKAISISKDEEWKRYRALLS 134

  Fly   129 PGFHFRILSEFKEPMEENCRILVRRLRTKA-NGESFDIYPYITLFALDAICETAMGIKKHAQLQS 192
            |.|....|.|....:|:...|||:.||.:| .|....:...:..:::|.|..|:.|:...:....
Mouse   135 PTFTSGRLKEMFPVIEQYGDILVKYLRQEAEKGMPVAMKDVLGAYSMDVITSTSFGVNVDSLNNP 199

  Fly   193 DSEYVQAVQSICRVMHKQSFSF-----------WQRLNV---------FFKHTKPGKEREAALKV 237
            :..:|:..:...||.......|           ::.||:         |||
Mouse   200 EDPFVEEAKKFLRVDFFDPLLFSVVLFPLLTPVYEMLNICMFPNDSIEFFK-------------- 250

  Fly   238 LHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLT-----QMEGGAELSDTDI 297
                 ..|.|::..:|              |...|.|:.||.:::.:     ..:.....|:.:|
Mouse   251 -----KFVDRMQESRL--------------DSNQKHRVDFLQLMMNSHNNSKDKDSHKAFSNMEI 296

  Fly   298 REEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASE-LEGREKES------MPYLEAVI 355
            ..:...|:..|::||||.::|.|..|:.:||:|::...|..: |..:...:      |.||:.|:
Mouse   297 TVQSIIFISAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKALPNKATPTCDTVMEMEYLDMVL 361

  Fly   356 KETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LVNEK 419
            .||||:||.|....|...:|:|:..:.:|||:.:....|.||.||:::||||.|.|:|| ..|:.
Mouse   362 NETLRLYPIVTRLERVCKKDVELNGVYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKENKG 426

  Fly   420 QMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQ-PKPLA-ELVTKSGNGIR 482
            .:.|:.:..|..|||||||.:||::.:|.::..:|:::.|.|.::.| |..|: :.:.:....|.
Mouse   427 SIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQETQIPLKLSRQGILQPEKPIV 491

  Fly   483 LRILPRD 489
            |:::|||
Mouse   492 LKVVPRD 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	CYP4	64..483	CDD:410721	117/456 (26%)
Cyp3a44	NP_796354.1	CYP3A	67..493	CDD:410743	118/459 (26%)