DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4ac3

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_608918.1	Gene:	Cyp4ac3 / 33756	FlyBaseID:	FBgn0031695	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	513	Identity:	181/513 - (35%)
Similarity:	272/513 - (53%)	Gaps:	59/513 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ALVAFVLWAAFLRYLPKILNFLRLQRFAKT------------LPGPT-IGEL--IANVKKGEILN 54
            :|:...|| ..||.|.|....|.|.:..:|            :||.| .|..  :.|:....|.:
  Fly     9 SLLIGALW-LLLRQLNKTYFILSLCKRVRTADGSPLESKVFVVPGKTRFGNNLDLLNLTPANIFS 72

  Fly    55 WLKELREKHGPVFRIW---FGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNG 116
            :::|...|......||   |..:..::  ..||.:::..:.::.||:.:|||:.|:||.|||.:.
  Fly    73 YIRESTAKANGQNYIWNFLFAPEYNIV--RAEDAEEIFQSTKITTKNMSYELIRPFLGDGLLISI 135

  Fly   117 GESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICETA 181
            .:.||.|||.|||.|||.||..|....:|..:..::.| .|..|...::...|..|.|:.|||||
  Fly   136 DQKWHTRRKTLTPAFHFNILQSFLSIFKEESKKFIKIL-DKNVGFELELNQIIPQFTLNNICETA 199

  Fly   182 MGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRL-------NVFFKHTKPGKEREAALKVLH 239
            :|:|.. .:...:||.:|:       |.....|.||:       |.:|......|:....|:.:|
  Fly   200 LGVKLD-DMSEGNEYRKAI-------HDFEIVFNQRMCNPLMFFNWYFFLFGDYKKYSRILRTIH 256

  Fly   240 DETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTF 304
            ..::.:|:.:|:|..|     |...:.|:.|.|:|.|.||.||..:.||  ::....|.:||:||
  Fly   257 GFSSGIIQRKRQQFKQ-----KQLGQVDEFGKKQRYAMLDTLLAAEAEG--KIDHQGICDEVNTF 314

  Fly   305 MFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASEL-EGREKESM------PYLEAVIKETLRIY 362
            ||.|:||||:::.|.|.||:.:.|||:|.:||..:| |..::.||      .:||.||||:||::
  Fly   315 MFGGYDTTSTSLIFTLLLLALHADVQERCYEELQDLPEDIDEVSMFQFNELIHLECVIKESLRLF 379

  Fly   363 PSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFL-VNEKQMHPFAF 426
            ||.|...|..:|:..:..|.:||.|.||..||.:.||.::||.|.:|.|:||| .|....|||||
  Fly   380 PSAPIIGRTCIEESVMNGLVLPKNAQISIHIYDIMRDARHFPKPNQFLPERFLPENSVNRHPFAF 444

  Fly   427 AAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLR 484
            ..|||||||||||||.:||:|..||.::|:::.||     ...|.:|..:  |||.||
  Fly   445 VPFSAGPRNCIGQKFGVLEIKVLLAAVIRNFKLLP-----ATQLEDLTFE--NGIVLR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	164/454 (36%)
Cyp4ac3	NP_608918.1	p450	51..504	CDD:278495	171/470 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460484
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	9	9.000