DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and AgaP_AGAP002211

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_565607.3	Gene:	AgaP_AGAP002211 / 3290581	VectorBaseID:	AGAP002211	Length:	505	Species:	Anopheles gambiae

Alignment Length:	481	Identity:	140/481 - (29%)
Similarity:	235/481 - (48%)	Gaps:	48/481 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 AFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANV--------KKGEILNWLKELREKHG 64
            |.:|....:.|..|:......|.|||.:|||....||.:.        :...::|   ||..|:|
Mosquito     6 ALILLLGLVLYWSKLSRKTSAQLFAKDIPGPRSYPLIGSAHLFLGSDERTFSVIN---ELFRKYG 67

  Fly    65 PVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKLLTP 129
            ..|::..|....:..:||:.|:|.|.::....|:..|..||  |..||:::....|...||.|.|
Mosquito    68 SFFKLSLGPKTFLCLSDPDLIQQALTSSACQDKAFFYRFLE--LDYGLISSRYTDWKLYRKSLNP 130

  Fly   130 GFHFRILSEFKEPMEENCRILVRRLRTKAN-GESFDIYPYITLFALDAICETAMGIKKHAQLQSD 193
            .|:.|||..|.........::|.|:..:|: .:.||...|.....|:.:|.::        |:||
Mosquito   131 AFNQRILISFISIFNRCSEVMVSRMAKEADRRQPFDALHYTAQCTLEMVCASS--------LKSD 187

  Fly   194 -------SEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRRE 251
                   .|...|::.:|.:|..:.|:.....::.|..|:..:|.:.....|....|.::..:||
Mosquito   188 ITDDPQAREACGAIEKMCAIMSSRLFNVLLYSDLLFTLTQRYREMQKVRVNLEHVVNPILYGKRE 252

  Fly   252 QLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAI 316
            :|.::|.:  ....:|:...::.:.|||.||.|| .||.:|...:|...:.|.:..|.:||::.:
Mosquito   253 RLSKQRLD--NAHSEDEEHYRKPMVFLDQLLHTQ-RGGRDLEMQEIENHLYTIIGAGSETTANQV 314

  Fly   317 AFALSLLSKNPDVQQRAFEEASELEGREK--------ESMPYLEAVIKETLRIYPSVPFFSRKVL 373
            ||.|.:::.:|:||.|..||...:.||..        .:..|||.|||||:|:||..|...|:.:
Mosquito   315 AFILLMIAMHPEVQDRVHEEIVSIYGRAAPDFSYETISAQTYLEQVIKETMRVYPVAPLIGRETI 379

  Fly   374 EDLEVGKLTVPKGASISCLIYMLHRDPK------NFPDPERFDPDRFLVNEKQMHPFAFAAFSAG 432
            |.:::|.:.||.|.::...|..|||:.:      :..||:||||  .|.:.|:.|||::..|..|
Mosquito   380 ETVKLGDVIVPSGVTLLINILTLHRNKELWGERAHVFDPDRFDP--ALYDAKKQHPFSYIPFGGG 442

  Fly   433 PRNCIGQKFAMLELKTSLAMLLRSYR 458
            ||||||.::.|..:|..:..:||.|:
Mosquito   443 PRNCIGYRYGMFAMKIMVTQVLRKYQ 468

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	132/454 (29%)
AgaP_AGAP002211	XP_565607.3	p450	34..472	CDD:278495	132/453 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
TreeFam	0	0.000	Not matched by this tool.
	3	2.810