DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and cyp26b1

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_997831.1	Gene:	cyp26b1 / 324188	ZFINID:	ZDB-GENE-030131-2908	Length:	511	Species:	Danio rerio

Alignment Length:	539	Identity:	130/539 - (24%)
Similarity:	216/539 - (40%)	Gaps:	103/539 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLA--LVAFVLWAAFLRYLPKILNFLRLQRFAKT------LPGP--TIGELIANVKKGEILNW 55
            ::|||  ||:..|..|..:.|.::       |:..|      ||.|  ::|..|.    ||..:|
Zfish    12 LATLAACLVSMALLLAVSQQLWQL-------RWTATRDKSCKLPMPKGSMGFPII----GETCHW 65

  Fly    56 L-------KELREKHGPVFRIWFGKDLMVMFTDPEDI-KQLLGNNQLLTKSRNYELLEPW----- 107
            .       ...|:|:|.||:.......::..|..|:: |.|:|.:.|:|..        |
Zfish    66 FFQGAGFHASRRQKYGNVFKTHLLGRPLIRVTGAENVRKVLMGEHSLVTVD--------WPQSTS 122

  Fly   108 --LGKGLLTNG-GESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRT-KANGESFDIYPY 168
              ||...|.|. |:...:|||:....|....|..:...:::   ::...||. .:|.:..::|..
Zfish   123 TLLGPNSLANSIGDIHRKRRKIFAKVFSHEALESYLPKIQQ---VIQETLRVWSSNPDPINVYRE 184

  Fly   169 ITLFALDAICETAMGIK-----KHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPG 228
            ....:.:......:|.:     .|....:..|:|:.|.|:             .:::.|...:.|
Zfish   185 SQRLSFNMAVRVLLGFRIPEEEMHCLFSTFQEFVENVFSL-------------PIDLPFSGYRKG 236

  Fly   229 -KEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAEL 292
             :.|::..|.:            |:.|:|    ||...|    .|.....||:||.:..|...||
Zfish   237 IRARDSLQKSI------------EKAIRE----KPLHTQ----GKDYTDALDVLLESAKENNTEL 281

  Fly   293 SDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEE-------------ASELEGRE 344
            :..:::|.....:|....||:||....:..|.::|.|.::..||             ..||....
Zfish   282 TMQELKESTIELIFAAFATTASASTSLVMQLLRHPAVLEKLREELRSCGLLHDGCLCQGELRLDS 346

  Fly   345 KESMPYLEAVIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERF 409
            ..|:.||:.||||.||::..|....|...:..|:..:.||||.|:...|...|.....|.|.|.|
Zfish   347 IISLKYLDCVIKEVLRLFAPVSGGYRIATQTFELDGVQVPKGWSVMYSIRDTHDTSAVFKDVEAF 411

  Fly   410 DPDRFLV--NEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAE 472
            |||||..  :|.:...|.:..|..|.|:|:|::.|.|.||.....|....||.......|:.::.
Zfish   412 DPDRFSPERSEDREGRFHYLPFGGGVRSCLGKQLATLFLKLLAVELAGGSRFELSTRTFPRMISV 476

  Fly   473 LVTKSGNGIRLRILPRDEN 491
            .|....:|:|::....|.|
Zfish   477 PVVHPTDGLRVKFFGLDSN 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	115/473 (24%)
cyp26b1	NP_997831.1	p450	1..489	CDD:299894	128/531 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910