DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4d2

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001284806.1	Gene:	Cyp4d2 / 31192	FlyBaseID:	FBgn0011576	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	509	Identity:	213/509 - (41%)
Similarity:	321/509 - (63%)	Gaps:	34/509 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLALVAF---VLWAAFLRYLPKILNFLRLQRFAKTLPGPT----IGELI--ANVKKGEILNWL 56
            :..|.||||   :||           :||..:|....||||.    :|.|:  ..:...:|::::
  Fly     5 VGVLLLVAFATLLLW-----------DFLWRRRGNGILPGPRPLPFLGNLLMYRGLDPEQIMDFV 58

  Fly    57 KELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWH 121
            |:.:.|:|.::|:|....|.|..|||.||:.:|.:.|.:||:..|:||..|||.|||.:.|..||
  Fly    59 KKNQRKYGRLYRVWILHQLAVFSTDPRDIEFVLSSQQHITKNNLYKLLNCWLGDGLLMSTGRKWH 123

  Fly   122 RRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGES-FDIYPYITLFALDAICETAMGIK 185
            .|||::||.|||:||.:|.|..::...::|.:|:::|:|.: .:|:|.|.|.|||.|.|||||.|
  Fly   124 GRRKIITPTFHFKILEQFVEIFDQQSAVMVEQLQSRADGMTPINIFPVICLTALDIIAETAMGTK 188

  Fly   186 KHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKP--GKEREAALKVLHDETNRVIRL 248
            .:||...:..|||||..:..::.|:....|||::..|:.|:|  .|.::.|:||:||.|..:||.
  Fly   189 INAQKNPNLPYVQAVNDVTNILIKRFIHAWQRVDWIFRLTQPTEAKRQDKAIKVMHDFTENIIRE 253

  Fly   249 RREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTS 313
            |||.|:....|..||.|.:.:|.|||:|.||:||.:.:: ||.|||.|||||||||||||||||:
  Fly   254 RRETLVNNSKETTPEEEVNFLGQKRRMALLDVLLQSTID-GAPLSDEDIREEVDTFMFEGHDTTT 317

  Fly   314 SAIAFALSLLSKNPDVQQRAFEEASELEGREKES---------MPYLEAVIKETLRIYPSVPFFS 369
            |||:|.|..:|::|:||||..:|..::.|.:::|         :.::|.||||:||::|.||...
  Fly   318 SAISFCLYEISRHPEVQQRLQQEIRDVLGEDRKSPVTLRDLGELKFMENVIKESLRLHPPVPMIG 382

  Fly   370 RKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGPR 434
            |...||:|:....:|.|.:.:..|::|.|||:.|..|:.|.|:||..:..|:||:|:..||||||
  Fly   383 RWFAEDVEIRGKHIPAGTNFTMGIFVLLRDPEYFESPDEFRPERFDADVPQIHPYAYIPFSAGPR 447

  Fly   435 NCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILPR 488
            |||||||||||:|::::.|||.:..|| ...:|:....:|.:|.||:.|.:.||
  Fly   448 NCIGQKFAMLEMKSTVSKLLRHFELLP-LGPEPRHSMNIVLRSANGVHLGLKPR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	196/451 (43%)
Cyp4d2	NP_001284806.1	p450	32..495	CDD:278495	199/464 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460453
Domainoid	1	1.000	151	1.000	Domainoid score	I1385
eggNOG	1	0.900	-	-		E33208_3B9GY
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	170	1.000	Inparanoid score	I1543
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG28797
OrthoDB	1	1.010	-	-		D10482at33392
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	1	1.000	-	-		mtm8393
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	P	PTHR24291
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
	12	11.810