DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4f18

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001028858.2	Gene:	Cyp4f18 / 290623	RGDID:	1305261	Length:	524	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	179/515 - (34%)
Similarity:	277/515 - (53%)	Gaps:	50/515 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVAFVLWAAFLRY-LPKIL----NFLRLQRFAKTLPGPT-------IGELIANVKKGEILNWLKE 58
            |:..|..:..|.| ||::.    |..||:||.:.   ||       :| ||.:.::|  |.:::.
  Rat    21 LLLLVGASCLLAYILPQVYAVFENSRRLRRFPQP---PTRNWLFGHLG-LIQSSEEG--LLYIQS 79

  Fly    59 LREKHGPVFRIWFGK-DLMVMFTDPEDIKQ-LLGNNQLLTKSR-NYELLEPWLGKGLLTNGGESW 120
            |......|...|.|. ..::....|..||. :|....:..|.| .|..|:||||.|||.:.|:.|
  Rat    80 LSRTFRDVCCWWVGPWHPVIRIFHPAFIKPVILAPASVAPKDRVFYRFLKPWLGDGLLLSTGDKW 144

  Fly   121 HRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGES--FDIYPYITLFALDAICETAMG 183
            .|.|.:|||.|||.||..:.:...::..|:..:.:..|:..|  .|::.:|:|..||::.:....
  Rat   145 SRHRHMLTPAFHFNILKPYVKIFNDSTNIMHAKWQRLASQGSARLDMFEHISLMTLDSLQKCVFS 209

  Fly   184 IKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRL 248
            ...:.| :..|||:.|:..:..::.::..|....:::|:..|:.|.....|.:::||.|:.|||.
  Rat   210 FDSNCQ-EKPSEYITAILELSALVARRHQSLLLYVDLFYHLTRDGMRFRKACRLVHDFTDAVIRE 273

  Fly   249 RREQLIQERNEWKPEAEQDD-VGAK---RRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGH 309
            ||..|        |:...|| :.||   :.|.|:|:|||::.|.|..|||.|||.|.|||||.||
  Rat   274 RRRTL--------PDQGGDDALKAKAKAKTLDFIDVLLLSKDEHGEALSDEDIRAEADTFMFGGH 330

  Fly   310 DTTSSAIAFALSLLSKNPDVQQRAFEEASE-LEGREKE--------SMPYLEAVIKETLRIYPSV 365
            |||:|.:::.|..|:|:|:.|:|..:|..| |..||.|        .:|:|...|||:||::|..
  Rat   331 DTTASGLSWILYNLAKHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHPPA 395

  Fly   366 PFFSRKVLEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LVNEKQMHPFAFA 427
            ...||...:|:.:  |:: :|||......|:..|.:|..:||||.::|.|| ..|.:...|.||.
  Rat   396 TAISRCCTQDIMLPDGRV-IPKGVICRISIFGTHHNPAVWPDPEVYNPFRFDADNGEGRSPLAFI 459

  Fly   428 AFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILP 487
            .|||||||||||.|||.|:|.:||:.|..:|.||| |.:|:...||:.::..|:.||:.|
  Rat   460 PFSAGPRNCIGQTFAMSEMKVALALTLLRFRVLPD-DKEPRRKPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	162/461 (35%)
Cyp4f18	NP_001028858.2	CYP4F	74..515	CDD:410772	159/451 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348452
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650