DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4f5

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_775147.1	Gene:	Cyp4f5 / 286905	RGDID:	708364	Length:	526	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	174/517 - (33%)
Similarity:	268/517 - (51%)	Gaps:	50/517 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LALVAFVLWAAFLRYLPKIL--------NFLRLQRFAKTLPGPT----IGELIANVKKGEILNWL 56
            |.|:....|     .|.:||        |..||:.|.::   |.    :|.|.......|.:..:
  Rat    21 LLLLGAASW-----ILARILAWTYSFCENCSRLRCFPQS---PKRNWFLGHLGTIQSNEEGMRLV 77

  Fly    57 KELREKHGPVFRIWFGKDLMVM-FTDPEDIKQLLGNNQLLT-KSRNY-ELLEPWLGKGLLTNGGE 118
            .|:.:....:...|.|..:.|: ..||..:..||....|:. |...: ..|:||||.||..:.|:
  Rat    78 TEMGQTFRDIHLCWLGPVIPVLRLVDPAFVAPLLQAPALVAPKDTTFLRFLKPWLGDGLFLSSGD 142

  Fly   119 SWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRR-----LRTKANGESFDIYPYITLFALDAIC 178
            .|.|.|:||||.|||.||..:.:...::..|:..:     |...|..|.|:   .|:|..||::.
  Rat   143 KWSRHRRLLTPAFHFDILKPYVKIFNQSVNIMHAKWKHLCLEGSARLEMFE---NISLMTLDSLQ 204

  Fly   179 ETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETN 243
            :...|...:.| :|.|||:.|:..:..::.|:|...:..|:..:..|..|:....|..::|:.|:
  Rat   205 KCLFGFDSNCQ-ESPSEYISAILELSSLIIKRSQQLFLYLDFLYYRTADGRRFRKACDLVHNFTD 268

  Fly   244 RVIRLRREQL-IQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFE 307
            .|||.||..| .|..:|:   .|.......:.|.|:|:|||.:.|.|.||||.|||.|.|||||.
  Rat   269 AVIRERRRLLSSQGTDEF---LESKTKSKSKTLDFIDVLLLAKDEHGKELSDEDIRAEADTFMFG 330

  Fly   308 GHDTTSSAIAFALSLLSKNPDVQQRAFEEASE-LEGREKE--------SMPYLEAVIKETLRIYP 363
            |||||:||:::.|..|:::|:.|:|..:|..| |..||.|        .:|:|...|||:||::|
  Rat   331 GHDTTASALSWILYNLARHPEYQERCRQEVWELLRDREPEEIEWDDLAQLPFLTMCIKESLRLHP 395

  Fly   364 SVPFFSRKVLEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LVNEKQMHPFA 425
            ......|:..:|:.:  |:: :|||......|:.:|.:|..:||||.|||.|| ..|.::..|.:
  Rat   396 PAIDLLRRCTQDIVLPDGRV-IPKGNICVISIFGIHHNPSVWPDPEVFDPFRFDSENRQKRSPLS 459

  Fly   426 FAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILP 487
            |..|||||||||||.|||.|:|..:|:.|..:|.||| |.:|:...|::.::..|:.||:.|
  Rat   460 FIPFSAGPRNCIGQTFAMNEMKVVVALTLLRFRVLPD-DKEPRRKPEIILRAEGGLWLRMEP 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	159/458 (35%)
Cyp4f5	NP_775147.1	p450	52..516	CDD:278495	161/475 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348430
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D249473at33208
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650