DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp4s3 and Cyp4f4

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_775146.1	Gene:	Cyp4f4 / 286904	RGDID:	708363	Length:	522	Species:	Rattus norvegicus

Alignment Length:	513	Identity:	178/513 - (34%)
Similarity:	278/513 - (54%)	Gaps:	45/513 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LVAFVLWAAFL--RYLPKILNFLRLQRFAKTLPGPT-----IGEL--IANVKKGEILNWLKELRE 61
            |:..::.|::|  |.|.:...|.|..:.....|.|.     :|.|  |...::|  |..:.:|..
  Rat    20 LLLLLIGASWLLVRVLTQTYIFYRTYQHLCDFPQPPKWNWFLGHLGMITPTEQG--LKQVTKLVA 82

  Fly    62 KHGPVFRIWFGKDL-MVMFTDPEDIKQLLGNNQ--LLTKSRNYELLEPWLGKGLLTNGGESWHRR 123
            .:...|..|.|..| ::....|:.|:.:|..:.  .|.:...|..|:||||.|||.:.|:.|...
  Rat    83 TYPQGFMTWLGPILPIITLCHPDVIRSVLSASASVALKEVIFYSFLKPWLGDGLLLSDGDKWSCH 147

  Fly   124 RKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGES--FDIYPYITLFALDAICETAMGIKK 186
            |::|||.|||.||..:.:...::..|:..:.:..|:|.|  .|::..|:|..||::.:.......
  Rat   148 RRMLTPAFHFNILKPYVKIFNDSTNIMHAKWQDLASGGSARLDMFKNISLMTLDSLQKCVFSFDS 212

  Fly   187 HAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRRE 251
            :.| :..|||:.|:..:..::.|:........:..::.|..|:....|.|::|:.|:.||:.||.
  Rat   213 NCQ-EKPSEYISAILELSALVAKRYQQLLLHTDSLYQLTHNGRRFHKACKLVHNFTDAVIQGRRR 276

  Fly   252 QLIQERNEWKPEAEQDDV-GAKRR---LAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTT 312
            .|        |...:||: .||.|   |.|:|:||||:.|.|.||||.|||.|.|||||||||||
  Rat   277 AL--------PSQHEDDILKAKARSKTLDFIDVLLLTKDEDGKELSDEDIRAEADTFMFEGHDTT 333

  Fly   313 SSAIAFALSLLSKNPDVQQRAFEEASELEGREKES----------MPYLEAVIKETLRIYPSVPF 367
            :|.:::.|..|:::|:.|:|..:|..||. |::||          :|:|...|||:||::|.|..
  Rat   334 ASGLSWILYNLARHPEYQERCRQEVRELL-RDRESTEIEWDDLAQLPFLTMCIKESLRLHPPVTV 397

  Fly   368 FSRKVLEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LVNEKQMHPFAFAAF 429
            .||:..:|:.:  |:: :|||......|:..|.:|..:||||.:||.|| ..|.|...|.||..|
  Rat   398 ISRRCTQDIVLPDGRV-IPKGVICIINIFATHHNPTVWPDPEVYDPFRFDPENIKDRSPLAFIPF 461

  Fly   430 SAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILP 487
            ||||||||||.|||.|:|.:||:.|..:|.||| |.:|:...||:.::..|:.||:.|
  Rat   462 SAGPRNCIGQTFAMNEMKVALALTLLRFRVLPD-DKEPRRKPELILRAEGGLWLRVEP 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	165/462 (36%)
Cyp4f4	NP_775146.1	CYP4F	74..515	CDD:410772	162/452 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348447
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650