DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and CYP4A22

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001010969.2	Gene:	CYP4A22 / 284541	HGNCID:	20575	Length:	519	Species:	Homo sapiens

Alignment Length:	511	Identity:	183/511 - (35%)
Similarity:	275/511 - (53%)	Gaps:	48/511 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 STLALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEILNWLKELREK---- 62
            |.|.|:..::.||.| ||.:......||:|    |.|....|..::::.:....|:.::|:
Human    23 SLLILLLLLIKAAQL-YLHRQWLLKALQQF----PCPPSHWLFGHIQEFQHDQELQRIQERVKTF 82

  Fly    63 -HGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSR-NYELLEPWLGKGLLTNGGESWHRRRK 125
             ....:.||.|| :.|...||:.:|.:||.:.  .||. :|:.|.|.:|.|||...|::|.:.|:
Human    83 PSACPYWIWGGK-VRVQLYDPDYMKVILGRSD--PKSHGSYKFLAPRIGYGLLLLNGQTWFQHRR 144

  Fly   126 LLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGES-FDIYPYITLFALDAICETAMGIKKHAQ 189
            :|||.||..||..:...|.::.|:::.:.......:| .:::.:::|..||.|.::|...:...|
Human   145 MLTPAFHNDILKPYVGLMADSVRVMLDKWEELLGQDSPLEVFQHVSLMTLDTIMKSAFSHQGSIQ 209

  Fly   190 LQSDSE-YVQAVQSICRVMHKQSFSFWQRLNVFFKH------TKPGKEREAALKVLHDETNRVIR 247
            :..:|: |:||:..:      .|..|....|.|.::      |..|:....|.::.|..|::||:
Human   210 VDRNSQSYIQAISDL------NSLVFCCMRNAFHENDTIYSLTSAGRWTHRACQLAHQHTDQVIQ 268

  Fly   248 LRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTT 312
            ||:.||       :.|.|.:.:..||.|.|||:|||.:||.|:.|||.|:|.|||||||||||||
Human   269 LRKAQL-------QKEGELEKIKRKRHLDFLDILLLAKMENGSILSDKDLRAEVDTFMFEGHDTT 326

  Fly   313 SSAIAFALSLLSKNPDVQQRAFEEASELEG-------REKESMPYLEAVIKETLRIYPSVPFFSR 370
            :|.|::.|..|:.:|..|:|..||...|.|       ...:.|||....|||.||:||.||...|
Human   327 ASGISWILYALATHPKHQERCREEIHGLLGDGASITWNHLDQMPYTTMCIKEALRLYPPVPGIGR 391

  Fly   371 KVLEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGP 433
            ::...:..  |: ::|||..:...||.||.:||.:|:.|.|||.||.....| |..||..||.|.
Human   392 ELSTPVTFPDGR-SLPKGIMVLLSIYGLHHNPKVWPNLEVFDPSRFAPGSAQ-HSHAFLPFSGGS 454

  Fly   434 RNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGI--RLRILP 487
            |||||::|||.:||.:.|:.|..:..|||....|.|:|.||.||.|||  |||.||
Human   455 RNCIGKQFAMNQLKVARALTLLRFELLPDPTRIPIPMARLVLKSKNGIHLRLRRLP 510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	158/456 (35%)
CYP4A22	NP_001010969.2	p450	52..505	CDD:278495	167/470 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154677
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3155
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.590