DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4v3

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001129072.1	Gene:	Cyp4v3 / 266761	RGDID:	708530	Length:	525	Species:	Rattus norvegicus

Alignment Length:	521	Identity:	204/521 - (39%)
Similarity:	298/521 - (57%)	Gaps:	50/521 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLWAA-----------FLRYLPKILNFLRLQRFAKTLPG-----PTIGELIANVKKG-----EIL 53
            :||.|           .|..|..::::.|..:..:.:|.     |.:|..:......     :|:
  Rat    14 LLWGAASAVSVAGATVLLNILQMLVSYARKWQQMRPIPSVARAYPLVGHALFMKPNNTEFFQQII 78

  Fly    54 NWLKELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGE 118
            .:.:|.|  |.|:.::|.|...:|.....|:::.:|.:::.:.||..|:.|:||||.||||:.|.
  Rat    79 QYTEEFR--HLPIIKLWIGPVPLVALYKAENVEVILTSSKQIDKSFMYKFLQPWLGLGLLTSTGS 141

  Fly   119 SWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMG 183
            .|..|||:|||.|||.||.:|.:.|.|...|||.:|....|.|:|:.:..|||.|||.|||||||
  Rat   142 KWRARRKMLTPSFHFTILEDFLDVMNEQANILVNKLEKHVNQEAFNCFFPITLCALDIICETAMG 206

  Fly   184 IKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRL 248
            ....||...|||||:.|..:..:::::....|...::::...|.|::.:..||.||..||.||..
  Rat   207 KNIGAQSNGDSEYVRTVYRMSDMIYRRMKMPWFWFDLWYLMFKEGRDHKKGLKSLHTFTNNVIAE 271

  Fly   249 RREQLIQERNEWKPEAEQDDVGAKR--------RLAFLDMLLLTQMEGGAELSDTDIREEVDTFM 305
            |    :..|     :||||.:||.|        |.||||:||....|.|.:||..||||||||||
  Rat   272 R----VNAR-----KAEQDCIGAGRGPLPSKTKRKAFLDLLLSVTDEEGNKLSHEDIREEVDTFM 327

  Fly   306 FEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEGR--------EKESMPYLEAVIKETLRIY 362
            |||||||::||.::|.||..||:||::..:|..::.||        :.:.:.||:.|||||||::
  Rat   328 FEGHDTTAAAINWSLYLLGSNPEVQRKVDKELDDVFGRSHRPVTLEDLKKLKYLDCVIKETLRVF 392

  Fly   363 PSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFL-VNEKQMHPFAF 426
            ||||.|:|.:.||.||....:.||.....:.|.|||||:.|||||.|.|:||. .|.:..||:|:
  Rat   393 PSVPLFARSLSEDCEVAGYKISKGTEAVIIPYALHRDPRYFPDPEEFQPERFFPENSQGRHPYAY 457

  Fly   427 AAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLA-ELVTKSGNGIRLRILPRDE 490
            ..||||||||||||||::|.||.||.:||.:....::..:...|| :|:.:..|||.:::..|.|
  Rat   458 VPFSAGPRNCIGQKFAVMEEKTILACILREFWIESNQKREELGLAGDLILRPNNGIWIKLKRRHE 522

  Fly   491 N 491
            :
  Rat   523 D 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	190/460 (41%)
Cyp4v3	NP_001129072.1	CYP4V	76..515	CDD:410773	193/449 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348389
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	1	1.100	-	-	O	PTHR24291
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.750