DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4f6

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_006241111.1	Gene:	Cyp4f6 / 266689	RGDID:	708365	Length:	538	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	179/525 - (34%)
Similarity:	272/525 - (51%)	Gaps:	68/525 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LALVAFVLWAAFLRYLPKIL--------NFLRLQRFAKTLPGPT--IGELIANVKKGEILNWLKE 58
            |.|:....|     .|.:||        |..||:.|.:. |.|:  .|.|.......|.:.::..
  Rat    22 LLLLGGASW-----ILARILAWIYTFYDNCCRLRCFPQP-PKPSWFWGHLTLMKNNEEGMQFIAH 80

  Fly    59 L----REKH----GPVFRIWFGKDLMVMFTDPEDIKQLLGNNQLLTKSRN--YELLEPWLGKGLL 113
            |    |:.|    |||:.|       :....|..|..||..:..:.....  |..|:||||.|||
  Rat    81 LGRNFRDIHLSWVGPVYPI-------LRLVHPNVIAPLLQASAAVAPKEMTLYGFLKPWLGDGLL 138

  Fly   114 TNGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRIL---VRRLRTKANGESFDIYPYITLFALD 175
            .:.||.|:..|:||||.|||.||..:.:...::...:   .:||..|.:.. .|::.:|:|..||
  Rat   139 MSAGEKWNHHRRLLTPAFHFDILKSYVKIFNKSVNTMHAKWQRLTAKGSAR-LDMFEHISLMTLD 202

  Fly   176 AICETAMGIKKHAQLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHD 240
            ::.:.......:.| :|:|||:.|:..:..::.|:....:..|:..:..|..|:....|..|:|:
  Rat   203 SLQKCIFSFDSNCQ-ESNSEYIAAILELSSLIVKRQRQPFLYLDFLYYLTADGRRFRKACDVVHN 266

  Fly   241 ETNRVIRLRREQL-IQERNEW-KPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDT 303
            .|:.|||.||..| .|..:|: |..|:      .:.|.|:|:|||.:.|.|..|||.|||.|.||
  Rat   267 FTDAVIRERRSTLNTQGVDEFLKARAK------TKTLDFIDVLLLAKDEHGKGLSDVDIRAEADT 325

  Fly   304 FMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASE-LEGREKE--------SMPYLEAVIKETL 359
            |||.|||||:||:::.|..|:::|:.|:|..:|..| |..||.|        .:|:|...|||:|
  Rat   326 FMFGGHDTTASALSWILYNLARHPEYQERCRQEVRELLRDREPEEIEWDDLAQLPFLTMCIKESL 390

  Fly   360 RIYPSVPFFSRKVLEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPE-----RFDPDRFLVN 417
            |::|.|...||...:|:.:  |:: :|||......|:.:|.:|..:||||     ||||:    |
  Rat   391 RLHPPVLLISRCCSQDIVLPDGRV-IPKGNICVISIFGVHHNPSVWPDPEVYNPFRFDPE----N 450

  Fly   418 EKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIR 482
            .::..|.||..|||||||||||.|||.|:|.:||:.|..:..||| |.:|:...||:.::..|:.
  Rat   451 PQKRSPLAFIPFSAGPRNCIGQTFAMSEIKVALALTLLRFCVLPD-DKEPRRKPELILRAEGGLW 514

  Fly   483 LRILP 487
            ||:.|
  Rat   515 LRVEP 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	163/466 (35%)
Cyp4f6	XP_006241111.1	p450	53..515	CDD:278495	166/483 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348433
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650