DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4a8

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_038965258.1	Gene:	Cyp4a8 / 266674	RGDID:	628846	Length:	510	Species:	Rattus norvegicus

Alignment Length:	483	Identity:	170/483 - (35%)
Similarity:	256/483 - (53%)	Gaps:	60/483 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 LNFLRLQRFAKTLPGPTIGELIANVKK--GEILNWLKELREKHGPVFRIWFGKDLMVMFTDPEDI 85
            |:||..|.|.         :::..||.  .....||             | |.::.:...||:.:
  Rat    64 LSFLVDQEFQ---------DILTRVKNFPSACPQWL-------------W-GSNVRIQVYDPDYM 105

  Fly    86 KQLLGNNQLLTKS-RNYELLEPWLGKGLLTNGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRI 149
            |.:||.:.  .|| .:|..|.||:|.|||...|::|.:.|::|||.||:..|..:...|.::.||
  Rat   106 KLILGRSD--PKSHHSYRFLAPWIGYGLLLLNGQTWFQHRRMLTPAFHYDTLKPYVGIMADSVRI 168

  Fly   150 LVRRLRTKANGES-FDIYPYITLFALDAICETAMGIKKHAQL-QSDSEYVQAVQSICRVMHKQSF 212
            ::.:.......:| .:|:.:|||..||.|.:.|...:...|| :....|::||:.:      .:.
  Rat   169 MLDKWEQIVGQDSTLEIFQHITLMTLDTIMKCAFSQEGSVQLDRKYKSYIKAVEDL------NNL 227

  Fly   213 SFWQRLNVFFKH------TKPGKEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGA 271
            ||::..|:|.::      :..|::..:|.::.|:.|::||:.|:.||       :.|.|...|..
  Rat   228 SFFRIRNIFHQNDIIYSLSSNGRKARSAWQLAHEHTDQVIKSRKAQL-------QDEEELQKVKQ 285

  Fly   272 KRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEE 336
            ||||.|||:||..::|.|:.|||.|:|.|||||||||||||:|.|::....|:.||:.||...:|
  Rat   286 KRRLDFLDILLFARIENGSSLSDKDLRAEVDTFMFEGHDTTASGISWIFYALATNPEHQQGCRKE 350

  Fly   337 ASELEG-------REKESMPYLEAVIKETLRIYPSVPFFSRKVLEDLEV--GKLTVPKGASISCL 392
            ...|.|       .:.:.|||....|||.|||||.|...||.:...:..  |: ::|||.::...
  Rat   351 IQSLLGDGASITWDDLDKMPYTTMCIKEALRIYPPVTAVSRMLSTPVTFPDGR-SLPKGITVMLS 414

  Fly   393 IYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSY 457
            .|.||.:|..:|:||.|||.|| ..|...|..:|..||.|.|||||::|||.|||.::|:.|..:
  Rat   415 FYGLHHNPTVWPNPEVFDPYRF-APESSRHSHSFLPFSGGARNCIGKQFAMNELKVAVALTLLRF 478

  Fly   458 RFLPDKDHQPKPLAELVTKSGNGIRLRI 485
            ..|||....|.|:..||.||.|||.||:
  Rat   479 ELLPDPTRIPIPIPRLVLKSKNGIYLRL 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	155/453 (34%)
Cyp4a8	XP_038965258.1	CYP4B-like	72..505	CDD:410771	164/472 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348414
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650