Protein Alignment Cyp4s3 and CYP4X1

DIOPT Version :9

• Sequence 1: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_828847.1
• Gene: CYP4X1 / 260293
• HGNCID: 20244
• Length: 509
• Species: Homo sapiens
• Alignment Length: 504
• Identity: 159/504 - (31%)
• Similarity: 254/504 - (50%)
• Gaps: 41/504 - (8%)

  Fly     7 VAFVLWAAFLRYLPKILNFLRLQRFAKTL---PGPTIGELIANVK--KGEILNWLKELREKHGPV 66
            :|||...| |..|..|..:||.||..:.|   |.|.....:.:.|  :.:.:..|:|:.||:...
Human    16 LAFVFCLA-LGLLQAIKLYLRRQRLLRDLRPFPAPPTHWFLGHQKFIQDDNMEKLEEIIEKYPRA 79

  Fly    67 FRIWFGK-DLMVMFTDPEDIKQLLG----NNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKL 126
            |..|.|. .......||:..|.||.    .:|.|.|     ...|.|||||....|..|.:.|:|
Human    80 FPFWIGPFQAFFCIYDPDYAKTLLSRTDPKSQYLQK-----FSPPLLGKGLAALDGPKWFQHRRL 139

  Fly   127 LTPGFHFRILSEFKEPMEENCRILVRRLR--TKANGESFDIYPYITLFALDAICETAMGIKKHAQ 189
            |||||||.||..:.|.|..:.::::.:..  ......|.::|.:|...:||.|.:.|...:.:.|
Human   140 LTPGFHFNILKAYIEVMAHSVKMMLDKWEKICSTQDTSVEVYEHINSMSLDIIMKCAFSKETNCQ 204

  Fly   190 LQSDSE-YVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQL 253
            ..|..: |.:|:..:.:::..:.:|.....::.||.:..|...:...:||:..|:.:|:.|::.|
Human   205 TNSTHDPYAKAIFELSKIIFHRLYSLLYHSDIIFKLSPQGYRFQKLSRVLNQYTDTIIQERKKSL 269

  Fly   254 IQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAF 318
                   :...:||:...::...|||::|..:.|.|:..||.|:..||.||:..||||.:::|::
Human   270 -------QAGVKQDNTPKRKYQDFLDIVLSAKDESGSSFSDIDVHSEVSTFLLAGHDTLAASISW 327

  Fly   319 ALSLLSKNPDVQQRAFEE-------ASELEGREKESMPYLEAVIKETLRIYPSVPFFSRKVLEDL 376
            .|..|:.||:.|:|..||       .|.:...:...|.|....||||.|:.|:||..||.:.:.|
Human   328 ILYCLALNPEHQERCREEVRGILGDGSSITWDQLGEMSYTTMCIKETCRLIPAVPSISRDLSKPL 392

  Fly   377 EV-GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRF-LVNEKQMHPFAFAAFSAGPRNCIGQ 439
            .. ...|:|.|.::...|:.||.:|..:.:|:.|||.|| ..|..|.||:|:..||||.||||||
Human   393 TFPDGCTLPAGITVVLSIWGLHHNPAVWKNPKVFDPLRFSQENSDQRHPYAYLPFSAGSRNCIGQ 457

  Fly   440 KFAMLELKTSLAMLLRSYRFLPDKDHQPKPLA---ELVTKSGNGIRLRI 485
            :|||:|||.::|::|..:|..||   ..:||.   ..:.|..||:.|.:
Human   458 EFAMIELKVTIALILLHFRVTPD---PTRPLTFPNHFILKPKNGMYLHL 503

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	142/455 (31%)
CYP4X1	NP_828847.1	p450	47..501	CDD:306555	146/468 (31%)
		heme binding region	447..460		10/12 (83%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165154667
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.750