Protein Alignment Cyp4s3 and Cyp3a23-3a1

DIOPT Version :10

• Sequence 1: NP_573003.2
• Gene: Cyp4s3 / 32444
• FlyBaseID: FBgn0030615
• Length: 495
• Species: Drosophila melanogaster
• Sequence 2: NP_037237.2
• Gene: Cyp3a23-3a1 / 25642
• RGDID: 628626
• Length: 502
• Species: Rattus norvegicus
• Alignment Length: 543
• Identity: 143/543 - (26%)
• Similarity: 244/543 - (44%)
• Gaps: 102/543 - (18%)

  Fly     1 MSTLALVAFVLWAAFLRYLPKILNFLRLQRFA---------KTLPGPTIGELIANVKKGEILNWL 56
            :|.|.|..:||.|..|         :.|..|.         :.:|||......     |.:||:.
  Rat     4 LSALTLETWVLLAVVL---------VLLYGFGTRTHGLFKKQGIPGPKPLPFF-----GTVLNYY 54

  Fly    57 K-------ELREKHGPVFRIWFGKDLMVMFTDPEDIKQLLGNN--QLLTKSRNYELLEPWLGKGL 112
            .       |..:|:|.::.::.|:..:...||.|.||.:|...  .:.|..|::..: ..:||.:
  Rat    55 MGLWKFDVECHKKYGKIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNRRDFGPV-GIMGKAI 118

  Fly   113 LTNGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAI 177
            ..:..|.|.|.|.||:|.|....|.|....:|:...|||:.|| :..|:...:......:::|.|
  Rat   119 SVSKDEEWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLR-QEKGKPVPVKEVFGAYSMDVI 182

  Fly   178 CETAMGIKKHAQLQSDSEYVQAVQSICRV-------MHKQSFSF----WQRLNV---------FF 222
            ..|:.|:...:.......:|:..:.:.|:       :....|.|    ::.||:         ||
  Rat   183 TSTSFGVNVDSLNNPKDPFVEKAKKLLRIDFFDPLFLSVVLFPFLTPVYEMLNICMFPKDSIEFF 247

  Fly   223 KHTKPGKEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLL----- 282
            |                   ..|.|::..:|              |...|.|:.||.:::
  Rat   248 K-------------------KFVYRMKETRL--------------DSVQKHRVDFLQLMMNAHND 279

  Fly   283 LTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASE-LEGREKE 346
            ....|....|||.:|..:...|:|.|::.|||.::|.|..|:.:||.|::..||... |..:...
  Rat   280 SKDKESHTALSDMEITAQSIIFIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRALPNKAPP 344

  Fly   347 S------MPYLEAVIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPD 405
            :      |.||:.|:.||||:||......|...:|:|:..:.:|||:.:....|.|||||:::|:
  Rat   345 TYDTVMEMEYLDMVLNETLRLYPIGNRLERVCKKDVEINGVFMPKGSVVMIPSYALHRDPQHWPE 409

  Fly   406 PERFDPDRF-LVNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQ-PK 468
            ||.|.|:|| ..|:..:.|:.:..|..|||||||.:||::.:|.:|..:|:::.|.|.|:.| |.
  Rat   410 PEEFRPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPL 474

  Fly   469 PLA-ELVTKSGNGIRLRILPRDE 490
            .|: :.:.:....|.|:::||||
  Rat   475 KLSRQGLLQPTKPIILKVVPRDE 497

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	CYP4	64..483	CDD:410721	121/455 (27%)
Cyp3a23-3a1	NP_037237.2	CYP3A	67..491	CDD:410743	122/458 (27%)