DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp3a18

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_665725.2	Gene:	Cyp3a18 / 252931	RGDID:	628709	Length:	497	Species:	Rattus norvegicus

Alignment Length:	536	Identity:	130/536 - (24%)
Similarity:	236/536 - (44%)	Gaps:	107/536 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 ALVAFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEILN-----WL--KELREK 62
            :|:.|.::..:...|.|.|.          :|||....|.     |.|.|     |.  .:..:|
  Rat    18 SLMLFYIYGTYSHGLFKKLG----------IPGPKPVPLF-----GTIFNYGDGMWKFDDDCYKK 67

  Fly    63 HGPVFRIWFGKDLMVMFTDPEDIKQLLGNN--QLLTKSRNYELLEPWLGKGLLTNGGESWHRRRK 125
            :|.::..:.|....:...|||.||.:|...  .:.|..|.:..: .::.|.:..:..|.|.|.|.
  Rat    68 YGKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNRRCFGPM-GFMKKAITMSEDEEWKRLRT 131

  Fly   126 LLTPGF-------HFRILSEFKEPMEENCRILVRRLRTKANGESFDIYPYITLFALDAICETAMG 183
            :|:|.|       .|.::.::.:.:.:|.|      |.:|.||..::......:::|.|..|:.|
  Rat   132 ILSPTFTSGKLKEMFPLMRQYGDTLLKNLR------REEAKGEPINMKDIFGAYSMDVITGTSFG 190

  Fly   184 IKKHAQLQSDSEYVQAVQSICR-------------------VMHKQSFSFW--QRLNVFFKHTKP 227
            :...:.......:||..:.|.:                   :....:||.:  |.:|.|.|..|.
  Rat   191 VNVDSLNNPQDPFVQKAKKILKFQIFDPFLLSVVLFPFLTPIYEMLNFSIFPRQSMNFFKKFVKT 255

  Fly   228 GKEREAALKVLHDETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAE- 291
            .|:            ||:                      |...|.|:.||.:::.||...|.|
  Rat   256 MKK------------NRL----------------------DSNQKSRVDFLQLMMNTQNSKGQES 286

  Fly   292 ---LSDTDIREEVDTFMFEGHDTTSSAIAFALSLLSKNPDVQQ-------RAFEEASELEGREKE 346
               |||.::..:...|:|.|:|.||::|:|.:..|:..|:||:       ||....:.:......
  Rat   287 QKALSDLEMAAQAIIFIFGGYDATSTSISFIMYELATRPNVQKKLQNEIDRALPNKAPVTYDALM 351

  Fly   347 SMPYLEAVIKETLRIYPSVPFFSRKVLEDLEVGKLTVPKGASISCLIYMLHRDPKNFPDPERFDP 411
            .|.||:.|:.|:||:||......|...:|:|:..:.:|||..::..||.|||:|:.:.:||.|:|
  Rat   352 EMEYLDMVVNESLRLYPIATRLDRVSKKDVEINGVFIPKGTVVTIPIYPLHRNPEYWLEPEEFNP 416

  Fly   412 DRF-LVNEKQMHPFAFAAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLP-DKDHQPKPLA-EL 473
            :|| ..|:..:.|:.:..|..|||||||.:||::.:|.::..:|:::...| :|...|..:: :.
  Rat   417 ERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKTQIPLKISRQP 481

  Fly   474 VTKSGNGIRLRILPRD 489
            :.:....|.|:::.||
  Rat   482 IFQPEGPIILKLVSRD 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	121/483 (25%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	114/465 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810