DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4x1

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_663708.1	Gene:	Cyp4x1 / 246767	RGDID:	628719	Length:	507	Species:	Rattus norvegicus

Alignment Length:	505	Identity:	165/505 - (32%)
Similarity:	261/505 - (51%)	Gaps:	36/505 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LALV---AFVLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVK--KGEILNWLKELREKH 63
            ||||   |.||..|...||.:    .||.|..:..||||...|:.:.|  :.:.:..|.|:.:::
  Rat    16 LALVFCLALVLMQAVKLYLRR----QRLLRDLRPFPGPTAHWLLGHQKFLQEDNMEKLDEIVKEY 76

  Fly    64 GPVFRIWFGK-DLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKLL 127
            ...|..|.|. .......||:..|..|......|:.. ::|:.|:||:|||...|..|.:.|.||
  Rat    77 PCAFPCWVGPFQAFFYIYDPDYAKIFLSRTDPKTQYL-HQLMTPFLGRGLLNLDGPRWFQHRCLL 140

  Fly   128 TPGFHFRILSEFKEPMEENCRILVRRL-RTKANGE-SFDIYPYITLFALDAICETAMGIKKHAQL 190
            ||.||..||....:.|..:..:::.:. :|....| :.:::.:|.|..||.|.:.|.|.:.:.|:
  Rat   141 TPAFHQDILKPCVDMMAHSVNMMLDKWEKTWTTQETTIEVFEHINLMTLDIIMKCAFGQETNCQI 205

  Fly   191 QSDSE-YVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQLI 254
            ....| ||:|...:..::..:.::||...::.||.:..|...:...||:|..|.::|:.|::.|
  Rat   206 NGTYESYVKATFELGEIISSRLYNFWHHHDIIFKLSPKGHCFQELGKVIHQCTEKIIQDRKKTL- 269

  Fly   255 QERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAFA 319
                  |.:..|||....:.  |||::|..|.......||.|:|.||:|||:.|||.::::|::.
  Rat   270 ------KDQVNQDDTQTSQN--FLDIVLSAQAGDEKAFSDADLRSEVNTFMWAGHDASAASISWL 326

  Fly   320 LSLLSKNPDVQQRAFEE-------ASELEGREKESMPYLEAVIKETLRIYPSVPFFSRKVLEDLE 377
            |..|:.||:.|.|...|       .|.:...:.:.:||....||||||:.|.:|..||::.:.|.
  Rat   327 LYCLALNPEHQDRCRTEIRSILGDGSSITWEQLDEIPYTTMCIKETLRLIPPIPSISRELSKPLT 391

  Fly   378 V--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFL-VNEKQMHPFAFAAFSAGPRNCIGQ 439
            :  |. ::|.|.::...|:.||.:|..:.||:.|||.||. .|.:|.||.||..||:||||||||
  Rat   392 LPDGH-SLPAGMTVVLSIWGLHHNPAVWKDPKVFDPLRFTKENSEQRHPCAFLPFSSGPRNCIGQ 455

  Fly   440 KFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRI--LP 487
            :|||||||.::|:.|..:|...|....|...:..|.:..:||.|.:  ||
  Rat   456 QFAMLELKVAIALTLLRFRVAADLTRPPAFSSHTVLRPKHGIYLHLKKLP 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	146/449 (33%)
Cyp4x1	NP_663708.1	CYP4B-like	66..500	CDD:410771	143/444 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348419
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750