DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4b1

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_058695.2	Gene:	Cyp4b1 / 24307	RGDID:	2480	Length:	511	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	173/503 - (34%)
Similarity:	261/503 - (51%)	Gaps:	39/503 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LWAAFLRYLPKILN----FLRLQRFAKTL---PGP----TIGELIANVKKG---EILNWLKELRE 61
            |||:.:..:..:|.    .||.|:.|:.:   |||    ..|..:...|.|   ::::|.::...
  Rat    15 LWASVVILMVIVLKLFSLLLRRQKLARAMDSFPGPPTHWLFGHALEIQKLGSLDKVVSWAQQFPH 79

  Fly    62 KHGPVFRIWFGKDL-MVMFTDPEDIKQLLGNNQLLTKSRN-YELLEPWLGKGLLTNGGESWHRRR 124
            .|    .:|||:.: .:...:|:..|.:.....  .|:.: |:....|:|||||...|..|.:.|
  Rat    80 AH----PLWFGQFVGFLNIYEPDYAKAVYSRGD--PKAADVYDFFLQWIGKGLLVLDGPKWFQHR 138

  Fly   125 KLLTPGFHFRILSEFKEPMEENCRILVRRLRTKAN-GESFDIYPYITLFALDAICETAMGIKKHA 188
            ||||||||:.:|..:.....|:.|:::.:...||: .:||||:..:...|||.:.:...|.....
  Rat   139 KLLTPGFHYDVLKPYVAIFAESTRMMLDKWEKKASENKSFDIFCDVGHMALDTLMKCTFGKGDSG 203

  Fly   189 QLQSDSEYVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDETNRVIRLRREQL 253
            ....|:.|..||..:..:|.::..||....:..:..|..|:....|.|:.||.|:.|||.|:..|
  Rat   204 LGHRDNSYYLAVSDLTLLMQQRIDSFQYHNDFIYWLTPHGRRFLRACKIAHDHTDEVIRQRKAAL 268

  Fly   254 IQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAF 318
                   :.|.|:..:..:|.|.|||:||..:.|.|.:|||.::|.|||||||||||||:|.|::
  Rat   269 -------QDEKERKKIQQRRHLDFLDILLGVRDESGIKLSDAELRAEVDTFMFEGHDTTTSGISW 326

  Fly   319 ALSLLSKNPDVQQRAFEEASELEGREKE-------SMPYLEAVIKETLRIYPSVPFFSRKVLEDL 376
            .|..::..|:.||...||...:.|.:..       .|.||...:||..|:||.||...|::.:.:
  Rat   327 FLYCMALYPEHQQLCREEVRGILGDQDSFQWDDLAKMTYLTMCMKECFRLYPPVPQVYRQLNKPV 391

  Fly   377 E-VGKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFL-VNEKQMHPFAFAAFSAGPRNCIGQ 439
            . |...::|.|:.||..||.|||:...:||||.|||.||. .|....|||||..|||||||||||
  Rat   392 TFVDGRSLPAGSLISLHIYALHRNSTVWPDPEVFDPLRFSPENAAGRHPFAFMPFSAGPRNCIGQ 456

  Fly   440 KFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRILP 487
            :|||.|:|...|:.|..:.|..|....|..:.:|:.:|.|||.|.:.|
  Rat   457 QFAMNEMKVVTALCLLRFEFSLDPSKMPIKVPQLILRSKNGIHLYLKP 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	158/455 (35%)
Cyp4b1	NP_058695.2	p450	47..500	CDD:278495	163/465 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348455
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650