DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4a2

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	XP_038965182.1	Gene:	Cyp4a2 / 24306	RGDID:	2479	Length:	517	Species:	Rattus norvegicus

Alignment Length:	501	Identity:	165/501 - (32%)
Similarity:	259/501 - (51%)	Gaps:	42/501 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 VLWAAFLRYLPKILNFLRLQRFAKTLPGPTIGELIANVKKGEILNWLKELREKHGPVFRIWF-GK 73
            ||:.|...||.:......|::|..|......|..:.:.:..::|.|:    ||.......|. |.
  Rat    30 VLFKAVQFYLRRQWLLKALEKFPSTPSHWLWGHNLKDREFQQVLTWV----EKFPGACLQWLSGS 90

  Fly    74 DLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGLLTNGGESWHRRRKLLTPGFHFRILSE 138
            ...|:..||:.:|.:||.:.    .:.|:.|.||:|.|||...|:.|.:.|::|||.||:.||..
  Rat    91 TARVLLYDPDYVKVVLGRSD----PKPYQSLAPWIGYGLLLLNGKKWFQHRRMLTPAFHYDILKP 151

  Fly   139 FKEPMEENCRILVRRL-RTKANGESFDIYPYITLFALDAICETAMGIKKHAQLQSDS-EYVQAVQ 201
            :.:.|.::..|::.:. :........:|:.|::|..||.:.:.|...:...||..:| .|.:||:
  Rat   152 YVKIMADSVSIMLDKWEKLDDQDHPLEIFHYVSLMTLDTVMKCAFSHQGSVQLDVNSRSYTKAVE 216

  Fly   202 SICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHDET-------------NRVIRLRREQL 253
            .:..::..:..|.:...::.:..:..|:....|.::.|:.|             :.||:.|:.||
  Rat   217 DLNNLIFFRVRSAFYGNSIIYNMSSDGRLSRRACQIAHEHTGSVFLLPAFLSLSDGVIKTRKAQL 281

  Fly   254 IQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFMFEGHDTTSSAIAF 318
                   :.|.|......||.|.|||:||..:||.|..|||.|:|.|||||||||||||:|.|::
  Rat   282 -------QNEEELQKARKKRHLDFLDILLFAKMEDGKSLSDEDLRAEVDTFMFEGHDTTASGISW 339

  Fly   319 ALSLLSKNPDVQQRAFEEASELEG-------REKESMPYLEAVIKETLRIYPSVPFFSRKVLEDL 376
            ....|:.:|:.|:|..||...:.|       ...:.|||....|||.||:|..||..||::...:
  Rat   340 VFYALATHPEHQERCREEVQSILGDGTSVTWDHLDQMPYTTMCIKEALRLYSPVPSVSRELSSPV 404

  Fly   377 EV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAFAAFSAGPRNCIGQ 439
            ..  |: ::|||..::.|||.||.:|..:|:|:.|||.||..:..: |..|:..||.|.|||||:
  Rat   405 TFPDGR-SIPKGIRVTILIYGLHHNPSYWPNPKVFDPSRFSPDSPR-HSHAYLPFSGGARNCIGK 467

  Fly   440 KFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRI 485
            :|||.|||.::|:.|..:..|||....|.|:..||.||.|||.||:
  Rat   468 QFAMNELKVAVALTLLRFELLPDPTRIPVPMPRLVLKSKNGIHLRL 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	147/458 (32%)
Cyp4a2	XP_038965182.1	CYP4B-like	69..512	CDD:410771	154/459 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166348413
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.650