DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp4s3 and Cyp4a29

DIOPT Version :9

Sequence 1:	NP_573003.2	Gene:	Cyp4s3 / 32444	FlyBaseID:	FBgn0030615	Length:	495	Species:	Drosophila melanogaster
Sequence 2:	NP_001093653.1	Gene:	Cyp4a29 / 230639	MGIID:	3717143	Length:	509	Species:	Mus musculus

Alignment Length:	514	Identity:	175/514 - (34%)
Similarity:	265/514 - (51%)	Gaps:	40/514 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSTLALVAFV------LWAAFLRYLPKIL-----NFLRLQRFAKTL---PGPTIGELIAN---VK 48
            :|.|:.:.|:      |...||..|..:|     ::||.|...:.|   |.|....|..:   .|
Mouse     3 ISALSPIRFLECVSGFLQVIFLIGLLLLLFKAAQHYLRRQWLLRALYQFPSPPSHWLFGHCLQFK 67

  Fly    49 KGEILNWLKELREKHGPVFRIW-FGKDLMVMFTDPEDIKQLLGNNQLLTKSRNYELLEPWLGKGL 112
            ..|.|.|:....||....|..| :|..:.:...||:.:|.:||...  .|:..|..|.||||.||
Mouse    68 VDEELRWILRYLEKFPGAFLHWIWGSHVFIKVCDPDYMKVILGRAD--PKASLYRFLTPWLGHGL 130

  Fly   113 LTNGGESWHRRRKLLTPGFHFRILSEFKEPMEENCRILVRRLRTKANGE-SFDIYPYITLFALDA 176
            ....|:.|.:.|:||||.||:.||..:...|.::.::::.:....|..: :.:|:..|:|..||.
Mouse   131 FFLNGDEWFQHRRLLTPAFHYDILKPYVGIMADSVQVMLEKWEQIACQDITLEIFHPISLMMLDT 195

  Fly   177 ICETAMGIKKHAQLQSDSE-YVQAVQSICRVMHKQSFSFWQRLNVFFKHTKPGKEREAALKVLHD 240
            |.:.|...:...||...|: |:|||..:..::..:..:.:...::.:..|...:...:|.::.|:
Mouse   196 IMKYAFSYQGSVQLDRSSQAYLQAVSDLNNLVTSRMKNVFLHNDIIYNLTSHSRRTNSACQIAHE 260

  Fly   241 ETNRVIRLRREQLIQERNEWKPEAEQDDVGAKRRLAFLDMLLLTQMEGGAELSDTDIREEVDTFM 305
            .|:||::||:.|| |:....|      .:..||.|.|||:|||::|:.|:.|||..:|.|||:.|
Mouse   261 HTDRVVKLRKAQL-QDNKSMK------KLRGKRCLDFLDILLLSRMDDGSSLSDKALRAEVDSLM 318

  Fly   306 FEGHDTTSSAIAFALSLLSKNPDVQQRAFEEASELEG-------REKESMPYLEAVIKETLRIYP 363
            |.||||.:|.|::....|:.:||.|||..||...|.|       .....|||....|||.||:||
Mouse   319 FGGHDTPASGISWVFYALATHPDHQQRCREEVQSLLGDGSPITWDHLHQMPYTTMCIKEALRLYP 383

  Fly   364 SVPFFSRKVLEDLEV--GKLTVPKGASISCLIYMLHRDPKNFPDPERFDPDRFLVNEKQMHPFAF 426
            .:|...||:...:..  |: ::|||.::....|.||.:||.:|:||.|||.||.:|..| |..||
Mouse   384 PIPSVGRKLSTPVTFPDGR-SLPKGITVLLHFYALHHNPKVWPNPEVFDPSRFAMNSVQ-HSHAF 446

  Fly   427 AAFSAGPRNCIGQKFAMLELKTSLAMLLRSYRFLPDKDHQPKPLAELVTKSGNGIRLRI 485
            ..||.|.|||||:..||..||.::|:.|..:..|||....|.|..:||.||.|||.|.:
Mouse   447 LPFSGGSRNCIGKHLAMNVLKVAVALTLLRFELLPDPSRVPIPTQQLVLKSKNGIYLHL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp4s3	NP_573003.2	p450	35..469	CDD:278495	155/451 (34%)
Cyp4a29	NP_001093653.1	p450	52..503	CDD:278495	162/461 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844968
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3B9GY
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1247045at2759
OrthoFinder	1	1.000	-	-		FOG0000016
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100014
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X23
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.650